Molekularna mašinerija za proizvodnju energije

undergraduate thesis

• Title (english): Molecular machinery involved in energy production
• Author: Frano Miloš
• Mentor: Ita Gruić Sovulj (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2014, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Najveći dio energije u obliku ATP-a se proizvodi u mitohondrijima. Stanični procesi uključeni u proizvodnju i pretvaranje energije u iskoristiv oblik trebaju izuzetno složenu molekularnu mašineriju. Desetljeća istraživanja strukture i funkcije respiratornih enzima su omogućila brojne spoznaje o mehanizmu sprege prijenosa elektrona i protona, no i dalje postoji mnogo nepoznanica. Cilj ovog seminarskog rada je opisati proces oksidativne fosforilacije te dati pregled svih enzima koji sudjeluju u tom procesu. Uključena su i nova saznanja o strukturi, mehanizmu i ulogama pojedinih respiratornih enzima. Također, opisana su i nova istraživanja specifičnih interakcija respiratornih enzima. Istraživanja strukture, sastava, uvjeta i mehanizama nastanka superkompleksa ukazuju na njihovu važnost i ulogu u mitohondrijima. Superkompleksi imaju uloge u regulaciji respiratorne aktivnosti i proizvodnje reaktivnih kisikovih radikala. Također, važni su i za pravilno sastavljanje kompleksa I te imaju utjecaj na morfologiju unutarnje membrane mitohondrija.

Abstract (english)

Most of the energy produced in the form of ATP is produced in the mitochondria. Cellular processes involved in energy production and conversion to more useful forms require highly complex molecular machinery. Decades of research into the structure and function of respiratory complexes have given valuable insights on the mechanism of coupling electron transfer to the translocation of protons but there are still many unresolved questions. The aim of this review is to describe the process of oxidative phosphorylation and to outline all enzymes involved. New insights into the structure, mechanism and functions of individual complexes are included. Also new studies of specific interactions of respiratory complexes are described. All the research on the structure, composition, mechanisms and conditions of assembly of supercomplexes indicate their great importance in the function of mitochondria. Supercomplexes have major roles in the regulation of respiratory activity and generation of reactive oxygen species. Also they are important for the correct assembly of complex I and have a large impact on the morphology of the inner mitochondrial membrane.

• Keywords: molekularna mašinerija; mitohondriji; proizvodnja energije
• Keywords (english): molecular machinery; mitochondria; energy production
• Language: croatian
• URN:NBN: urn:nbn:hr:217:925925
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-08 13:30:29