Povezanost upale i depresije

undergraduate thesis

• Title (english): The connection between inflammation and depression
• Author: Klara Filek
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2015, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Klinička depresija, jedan od najčešćih psihijatrijskih poremećaja i vodeći uzrok invalidnosti u svijetu, manifestira se kroz loše raspoloženje, anhedoniju, umor, manjak apetita i libida utječući na osnovne biološke procese drastično smanjujući kvalitetu života oboljelih. Prepoznata manjkavost objašnjenja najpopularnije serotonergične disfunkcije i pretjeranog lučenja kortizola potakla je širenje područja istraživanja etiologije depresije. Novija poveznica između upale i depresije pokazuje potencijal u rješavanju dijela dosad nerazriješene patofiziologije depresije. Poznato je da izazivanjem upale kod laboratorijskih životinja one počinju pokazivati takozvano depresivno ponašanje, te da tretman INF-α kod pacijenata oboljelih od hepatitisa C izaziva jake simptome depresije. Komplicirani međuodnosi citokina, neurotransmitera, stresnog odgovora i ostalih čimbenika uključenih u upalni proces dovode do zaključka da upala ima veliku ulogu u depresiji unatoč ponekad kontradiktornim rezultatima. Kod pacijenata s akutnom i kroničnom depresijom redovito su pronađene više razine upalnih citokina (IL-1, IL-6, TNF-α) u serumu i cerebrospinalnoj tekućini. Povezanost upale i depresije može se preslikati i na ostale psihijatrijske bolesti poput shizofrenije, bipolarnog poremećaja i Alzheimerove bolesti. Time saznanja iz područja imunologije se mogu korisiti i u razvoju novih terapijskih pristupa oboljelima od depresije.

Abstract (english)

Major depressive disorder, one of the most common psychiatric disorders and leading cause of disability worldwide, presents itself through low mood, anhedonia, fatigue, loss of appetite and libido affecting fundamental biological processes and drastically lowering patients’ quality of life. Recognized shortcomings of popular serotonergic dysfunction and over secretion of cortisol in explaining depression encouraged research into the unknown processes of depression etiology. Newer connections between inflammation and depression show great potential in presenting the missing puzzle pieces of, to this day, unsolved pathophysiology of depression. Inducing inflammation in laboratory animals leads to manifestation of sickness behavior and INF-α treatments used in human patients with hepatitis C leads to patients exhibiting major symptoms of depression. Complicated interplay of cytokines, neurotransmitters, stress response and other factors included in inflammation impose a conclusion of inflammation having a great role in depression in spite of sometimes contradictory results. In patients with acute and chronic depression increased levels of proinflammatory cytokines (IL-1, IL-6, TNF-α) are regularly found in blood serum and cerebrospinal fluid. The connection between inflammation and depression can be translated to other psychiatric diseases such as schizophrenia, bipolar disorder and Alzheimer’s disease. Therefore, the insights from immunology can be used in developing new therapeutic approaches in treating depression.

• Keywords: upala; depresija
• Keywords (english): inflammation; depression
• Language: croatian
• URN:NBN: urn:nbn:hr:217:214077
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-14 13:59:05