Genetika karcinoma kolona

undergraduate thesis

• Title (english): Genetics of colon cancer
• Author: Matea Brezak
• Mentor: Petra Korać (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2016, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Karcinom debelog crijeva maligni je epitelni tumor i jedan od najčešćih oblika malignih novotvorevina koje zahvaćaju oba spola. Unatoč još uvijek visokoj stopi mortaliteta, posljednjih desetak godina učestalost ovog karcinoma se smanjuje, ali još uvijek predstavlja veliki zdravstveni problem. Prema uzroku nastanka možemo ga podijeliti na obiteljski, nasljedni i sporadični oblik. Istraživanjem nasljednih sindroma poput obiteljske adenomatozne polipoze i nasljednog nepolipoznog kolorektalnog karcinoma otkrivene su promjene gena APC, MMR, KRAS i TP53 uključenih i u razvoj sporadičnog karcinoma. Razvitkom metoda istraživanja otkriveni su i neki manje učestali sindromi te geni koji se s njima povezuju. Istraživanjem gena EPCAM, MUTYH, SMAD4 i STK-11 koji sudjeluju u nastanku rijetkih sindroma i ranije otkrivenih primjera drugih gena otkriveni su mehanizmi karcinogeneze što je omogućilo razvitak preciznijih metoda liječenja. Unatoč značajnom broju novootkrivenih promjena u različitim genima potrebno je nastaviti istraživanja da bi se u potpunosti razumjeli priroda i značaj procesa razvoja karcinoma debelog crijeva.

Abstract (english)

Colorectal cancer is a malignant epithelial tumor and one of the most common forms of malignancies that affect both man and women. Despite high rate of mortality, incidence of this cancer is decreasing, but still represents a major health issue. According to the origin, it can be divided into family, hereditary and sporadic form. By studying hereditary syndromes such as FAP and HNPCC, mutations in APC, MMR, KRAS and p53 genes are found. Mutations of these genes are part of cancerogenesis in sporadic forms of colorectal cancer as well as in hereditary syndromes. With development of research methods some less common syndromes and mutations in associated genes have been discovered. Mechanisms of carcinogenesis were understood by studying EpCAM, MUTYH, SMAD4 and STK-11 genes that are included in development of rare syndromes and previously discovered mutations of diferent genes. Research of its carcinocenesis has contributed to development of more precise treatment methods. Despite the significant number of newly discovered mutated genes, it is necessary to continue research in this field to understand the nature and significance of the colon cancer cancerogenesis.

• Keywords: karcinom debelog crijeva
• Keywords (english): colorectal cancer
• Language: croatian
• URN:NBN: urn:nbn:hr:217:390769
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-12-22 11:00:21