Funkcije biogenih amina kao neurotransmitera u središnjem živčanom sustavu

undergraduate thesis

• Title (english): Functions of biogenic amines as neurotransmitters in the central nervous system
• Author: Dora Kolić
• Mentor: Vesna Benković (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2016, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Biogeni amini kao neurotransmiteri imaju brojne uloge u fiziološkim funkcijama i sudjeluju u širokom spektru ponašanja organizma i raznim kognitivnim fenomenima. Sintetiziraju se iz aminokiselina u živčanom sustavu i mogu se podijeliti na kateholamine, indolamine i imidazolamine. Patogeneza i etiologija raznih neuroloških bolesti i razvoj ovisnosti o drogama i supstancama poput nikotina i kofeina povezane su s promijenjenom signalizacijom biogenih amina. U ovom radu izložen je pregled puteva sinteze biogenih amina iz aminokiselina, specifični receptori na koje se vežu te brojne uloge koje amini vrše kao neurotransmiteri u centralnom živčanom sustavu. Amini su većinom djelovanjem povezani s drugim spojevima i mogu imati inhibitornu ili ekscitacijsku aktivnost. Determinacija specifičnih uloga pojedinog amina otežana je zbog njihovih kompleksnih interakcija i zbog same složenosti živčanog sustava. Mnoge dosad otkrivene funkcije amina zbog toga nisu u potpunosti objašnjene.

Abstract (english)

Biogenic amines as neurotransmitters have numerous roles in physiological functions and take part in a wide spectre of behaviours and many cognitive phenomena. They are synthesized from aminoacids in the nervous system and are divided into catecholamines, indoleamines and imidazoleamines. Patogenesis and etyology of many neurological diseases and development of drug, caffeine and nicotine addictions are connected to changes in biogenic amines signalization pathways. This work represents a review of biogenic amines synthesis pathways, specifical receptors which amines bind to and numerous roles which they carry out as neurotransmitters in the central nervous system. Amine activity is mostly connected to other compounds and they can have inhibitory or excitatory effect. Determination of specific amine roles is made difficult because of their complicated interactions and because of the complexity of the nervous system. This is the reason why many amine functions discovered so far haven't been completely explained.

• Keywords: biogeni amini; neurotransmiteri; živčani sustav
• Keywords (english): biogenic amines; neurotransmitters; nervous system
• Language: croatian
• URN:NBN: urn:nbn:hr:217:166390
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-03 08:51:20