Molekularna osnova socijalno-reproduktivnih ponašanja

undergraduate thesis

• Title (english): Molecular basis of social and reproductive behaviour
• Author: Tila Medenica
• Mentor: Duje Lisičić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2016, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Manje od 10% vrsta sisavaca pokazuje monogamno reproduktivno ponašanje. Među njima je i Microtus ochrogaster, prerijska voluharica koja se zbog svog jedinstvenog ponašanja naspram drugih voluharica roda Microtus počela koristiti kao alternativni modelni organizam glodavca u neurofiziološkim istraživanjima ponašanja umjesto klasičnih miševa i štakora. Ovaj rad pruža pregled nekoliko istraživačkih radova koji su pokazali kako je za monogamno ponašanje mužjaka odgovorna povećana koncetracija vazopresinskih V1a receptora u nucleus accumbensu i ventralnom pallidumu, što je par uzorkovano proširenim mikrosatelitnim slijedom u promotorskoj regiji gena za V1a receptor. Analogno tome, takve regije postoje i kod ljudi; RS3 mikrosatelitna regija u promotoru AVRP1A je izrazito polimorfna. Muškarci koji posjeduju alel 334 lokusa RS3 imaju značajno više problema u braku ili ih značajno veći postotak uopće nije u braku za razliku od muškaraca koji nemaju alel 334.

Abstract (english)

Less than 10% of all mammal species have a monogamous social structure. One of the species that exhibit this type of behavior is Microtus ochrogaster, prarie vole, which has been used in the last decade as a model organism for neuroendocrine research on reproductive behavior. Research has shown that monogamous voles have increased concentration of vasopressin receptors in nucleus accumbens and ventral pallidum areas of the brain. Gene for vasopressin 1a receptor shows polymorphism of repetitive microsatellite sequence in the regulatory promotor region among vole species. Monogamous voles have an expansion of repetitive microsatellite DNA whereas promiscuous speceis do not. Although there is no sequence in the human AVPR1A homologous to the one found in monogamous voles, humans do have polymorphic sequences in this region associated with partner bonding, martial problems and marital status in general.

• Keywords: socijalno-reproduktivno ponašanje
• Keywords (english): social and reproductive behaviour
• Language: croatian
• URN:NBN: urn:nbn:hr:217:045641
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-03 10:12:23