Validacija metode za određivanje bisfenola A i benzofenona u termokromnim bojama tekućinskom kromatografijom visoke djelotvornosti

master's thesis

• Title (english): Validation of the method for determination of bisphenol A and benzophenone in printing inks by high performance liquid chromatography
• Author: Magdalena Gavran
• Mentor: Nives Galić (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Vesna Petrović Peroković (član povjerenstva)
• Committee member: Željka Soldin (član povjerenstva)
• Committee member: Iva Juranović Cindrić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2017-02-14, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Uporaba endokrino aktivnih tvari kao što je bisfenol A za sintezu različitih materijala predstavlja sve veći problem zbog njihova djelovanja na hormonsku ravnotežu kod ljudi i životinja. Pseudoestrogeni bisfenol A i benzofenon mogu biti sastojci termokromnih boja bitni za njihovo funkcioniranje. Bisfenol A ima ulogu razvijača boje, a benzofenon se koristi kao fotoinicijator u bojama koje se suše pomoću UV zračenja. Uporaba termokromnih boja je u porastu, a koriste se u raznim tipovima "pametne" ambalaže, za sigurnosni tisak, u komercijalne svrhe te za različite vrste temperaturnih indikatora. Široka uporaba predstavlja povećani rizik intoksikacije ljudi i zagađenja okoliša endokrino aktivnim tvarima koje termokromne boje sadrže. U sklopu ovog diplomskog rada validirana je metoda za određivanje bisfenola A i benzofenona u termokromnim tiskarskim bojama po parametrima koje propisuju smjernice međunarodnih organizacija. Validirani parametri su specifičnost, selektivnost, linearnost, preciznost, točnost i robustnost. Validiranom metodom određen je sadržaj bisfenola A i benzofenona u 15 uzoraka termokromnih boja različitih proizvođača, načina tiska i sušenja.

Abstract (english)

Use of the endocrine disruptors like bisphenol A for the synthesis of different materials represents a growing problem due to their impact on the hormone balance in humans and animals. Pseudo-estrogenes bisphenol A and benzophenone may be important ingredients for the activity of thermochromic printing inks. Bisphenol A has a role of the colour developer and benzophenone is used as a photo-initiator in the UV-curing inks. Thermochromic printing inks are increasingly used in various types of ''smart'' packaging, security printing, for commercial purposes and different types of temperature indicators. Widespread use represents increasing fate of intoxication of humans and environmental pollution by the endocrine disruptors contained in the thermochromic printing inks. In this diploma thesis the method for determination of bisphenol A and benzophenone in thermochromic printing inks has been validated according to parameters prescribed in guidelines of the international organisations. Validated parameters were specificity, selectivity, linearity, precision, accuracy and robustness. The validated method was applied for bisphenol A and benzophenone analyses in 15 samples of thermochromic printing inks of various producers, printing and drying modes.

• Keywords: benzofenon; bisfenol A; tekućinska kromatografija visoke djelotvornosti; termokromne boje; validacija
• Keywords (english): benzophenone; bisphenol A; high pressure liquid chromatography; thermochromic printing inks; validation
• Language: croatian
• URN:NBN: urn:nbn:hr:217:232308
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-02-20 12:59:29