Asimetrična dioba stanice i „diferencijalno nasljeđivanje starosti“

undergraduate thesis

• Title (english): Asymmetric cell division and “differential inheritance of aging“
• Author: Viktorija Herceg
• Mentor: Dunja Leljak-Levanić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2009, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Asimetričnom staničnom diobom nastaju stanice kćeri koje su međusobno različite. Pri takvoj diobi dolazi do diferencijalnog nasljeđivanja centrosoma, molekula DNA, molekula RNA, proteina i proteinskih agregata. Kod viših eukariota asimetrična je dioba osnovni mehanizam diferencijacije stanica. S evolucijskog gledišta asimetričnu staničnu diobu možemo povezati s procesom starenja. U ovom radu uspoređeni su mehanizmi nasljeđivanja navedenih staničnih komponenti pri asimetričnoj diobi stanica različitih vrsta. Zbog njihove jednostavnosti, povezanost asimetrične diobe i starenja najbolje se može istražiti kod bakterija i kvasca. Centrosomi, kompartimentalizacija i citoplazmatski mikrotubuli su stanične strukture zadužene za nejednaku raspodjelu determinanti u stanice kćeri nastale asimetričnom diobom. U cilju boljeg razumijevanja povezanosti asimetrične stanične diobe i procesa starenja potrebno je unaprijediti postupke vizualizacije mikrotubula te lokalizacije proteina i molekula RNA.

Abstract (english)

Asymmetric cell division is a proces in which different daughter cells arise. During that division there is a differential inheritance of centrosomes, DNA molecules, RNA molecules, proteins and protein aggregates. In higher eukaryotes, asymmetric cell division is a fundamental mechanism of cell differentiation. From the evolutionary point of view, asymmetric cell division can be related with aging process. In this work, mechanisms of cell components inheritance during asymmetric cell division in different organisms were compared. Because of their simplicity, bacteria and yeast are the best organisms to study the relation between asymmetric cell division and aging process. Centrosomes, compartimentalization and cytoplasmic microtubules are structures responsible for differential distribution of determinants in two daughter cells during asymmetric cell division. In the purpose of better understanding the relation between asymmetric cell division and aging process it is needed to improve the quality of methods required for microtubules visualization and protein and RNA localization.

• Keywords: asimetrična stanična dioba; diferencijalno nasljeđivanje starosti
• Keywords (english): asymmetric cell division; differential inheritance of aging
• Language: croatian
• URN:NBN: urn:nbn:hr:217:244212
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-08 11:56:37