Sastavnice propolisa i njegova imunoadjuvatna svojstva

undergraduate thesis

• Title (english): Propolis constituents and its immunoadjuvant properties
• Author: Mateja Kralj
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2009, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Propolis ili pčelinje ljepilo koje pčele koriste za zatvaranje pukotina na svojim košnicama prepozat je kao ljekovito sredstvo još od antičkih vremena. Zbog svog kemijskog sastava, tj. bioaktivnih sastavnica posjeduje mnoga pozitivna svojstva. Kemijski sastav propolisa je raznolik, i uglavnom ovisi o njegovom porijeklu. Do danas je utvrđeno preko 300 različitih sastavnica, od kojih važno mjesto u istraživanjima ljekovitih svojstava propolisa imaju flavonoidi. Iako još nisu u potpunosti razjašnjeni mehanizmi njegova djelovanja, temeljem dosadašnjih istraživanja i iskustava propolis se smatra sigurnim i učinkovitim suučesnikom u imunomodulaciji. Njegovo imunomodulacijsko djelovanje ovisi o njegovom sastavu, metodi ekstrakcije i načinu primjene. Imunostimulacijska aktivnost propolisa se očituje u aktivnosti makrofaga i NK stanica, te staničnom i humoralnom odgovoru imunološkog sustava. Također, u slučajevima autoimunih bolesti i transplantacije organa, zbog učinka sličnog imunosupresijskim lijekovima, propolis bi se mogao koristiti u kombinaciji s njima ili kao njihova zamjena. Brojna istraživanja provedena u laboratorijima diljem svijeta kao i klinička iskustva stečena kod brojnih bolesti, upućuju na široki terapijski potencijal propolisa. Daljnja istraživanja mogla bi razjasnit načine njegova djelovanja i time omogućiti njegovu širu upotrebu u prevenciji i liječenju bolesti.

Abstract (english)

Propolis or bee glue that bees use as a sealant for unwanted open spaces in the hive has been recognized as a healing agent since ancient times. Because of its chemical composition, that is bioactive constituents, it possesses many positive characteristics. Chemical composition of propolis varies, and mainly depends of its origin. Over 300 different constituents have been determined to this day, of which flavonoids have an important place in propolis’s healing agents research. Although the mechanism of its acting is not yet cleared, on grounds of researches conducted so far, propolis is considered a safe and efficient accomplice in immunomodulation. Its immunomodulation effect depends of its composition, method of extraction and the way of application. Immunostimulative activity of propolis can be observed through activity of macrofages and NK cells, and through the cellular and humoral responses of immune system. Also, propolis has an effect similar to immunosupresor drugs, so, in cases like auto immune diseases and organ transplant, it could be used in synergy with them or as their substitute. Many researches conducted around the world as well as clinical experiences obtained from many diseases, indicate a wide therapeutical potential of propolis. Further researches could clear the mechanisms of its doing and therefore provide a wider usage in prevention and curing diseases.

• Keywords: propolis; pčelinje ljepilo
• Keywords (english): propolis; bee glue
• Language: croatian
• URN:NBN: urn:nbn:hr:217:023820
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-13 09:45:39