Paralozi aminoacil-tRNA-sintetaza

undergraduate thesis

• Title (english): Paralogs of aminoacyl-tRNA synthetases
• Author: Inja Radman
• Mentor: Ivana Weygand-Đurašević (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2009, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Aminoacil-tRNA-sintetaze ključni su enzimi u biosintetskom putu proteina i jedni od evolucijski najstarijih enzima. Analizama njima homolognih genskih sekvenci i proteinskih struktura utvrđeno je postojanje cijelog spektra tzv. krnjih paraloga, koji su funkcionalno uglavnom divergirali od svojih originala u više različitih smjerova. Ovim radom napravljen je osvrt na gotovo sve skupine otkrivenih paraloga te je izložena i komentirana funkcija, struktura i evolucija najzanimljivijih od njih. Paralozi su svrstani prema svojstvu homologije koju nose u dvije veće skupine, ovisno o tome sadrže li sekvencu homolognu katalitičkoj domeni odgovarajuće aaRS ili ne. Poseban je naglasak stavljen na nedavno otkrivene paraloge specifičnog metanogenog tipa seril-tRNA-sintetaza, čije su detaljne biokemijske i strukturalne analize upravo u tijeku.

Abstract (english)

Aminoacyl-tRNA synthetases are one of the key enzymes in protein biosynthesis and one of the evolutionary oldest enzymes as well. By analyses of their homologic sequences and protein structures, the existance of a wide spectrum of socalled truncated paralogs, which have mostly functionaly diverged from their originals into several different new pathways, has been shown. In this work a critical review of almost all groups of determined paralogs has been made. Also, function, structure and evolution of the most interesting ones has been established and commented. Paralogs have been divided into two larger subgroups based on their homology characteristics, depending on the homologous catalytic domain possesion. A special emphasis has been put on recently discovered methanogenic seryl-tRNA synthetases paralogs, whose detailed biochemical and structural analyses have just been in progress.

• Keywords: paralozi; aminoacil-tRNA-sintetaze
• Keywords (english): paralogs; aminoacyl-tRNA synthetases
• Language: croatian
• URN:NBN: urn:nbn:hr:217:043221
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-16 10:45:04