Imunološki sustav kože

undergraduate thesis

• Title (english): Skin immune system
• Author: Andrea Gubaš
• Mentor: Nada Oršolić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2011, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Primarna uloga kože jest mehanička zapreka, te je kao takva ključan organ kod urođene, nespecifične imunosti. No, ukoliko patogen ili neki drugi okolišni čimbenik prebrodi tu zapreku, u koži se aktivira niz različitih mehanizama koji mogu pokrenuti specifičan imunološki odgovor. U koži može doći do staničnog imunološkog odgovora, čiji su posrednici stanice imunološkog sustava, ali i neke druge stanice karakteristične za kožu, te može doći i do humoralnog imunološkog odgovora, posredovanog topljivim tvarima poput protutijela, citokina, kemokina, antimikrobnih peptida i ostalih. Kožne bolesti poput atopičkog dermatitisa, psorijaze, akni ili tumora zahvaćaju velik postotak ljudske populacije, te nastaju kako zbog genetičkih, tako i zbog imunoloških poremećaja.

Abstract (english)

Primary function of the skin is a mechanical barrier, which makes it a key organ of native, unspecific immune system. But, if some patogen or any other enviromental factor enters through that barrier, a series of different mechanisms in skin are activated and therefore can be induced a specific immunological response. Immunological responses in skin can be cellular, in which mediators are immunological or other skin cells, or they can be humoral, in which mediators are soluble substances like antibodies, cytokines, chemokines, antimicrobial peptides, complements and other. Skin diseases like atopic dermatitis, psoriasis, acne or tumors affect high percentage of human population, and their origin could be a concequence after some genetical or immunological disorder.

• Keywords: koža; imunološki sustav kože
• Keywords (english): skin; skin immune system
• Language: croatian
• URN:NBN: urn:nbn:hr:217:428916
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-06 07:44:11