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undergraduate thesis
RNA helikaze
2012. urn:nbn:hr:217:735463
Kovačević, Alen
University of Zagreb
Faculty of Science
Department of Biology

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Kovačević, A. (2012). RNA helikaze (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:735463

Kovačević, Alen. "RNA helikaze." Undergraduate thesis, University of Zagreb, Faculty of Science, 2012. https://urn.nsk.hr/urn:nbn:hr:217:735463

Kovačević, Alen. "RNA helikaze." Undergraduate thesis, University of Zagreb, Faculty of Science, 2012. https://urn.nsk.hr/urn:nbn:hr:217:735463

Kovačević, A. (2012). 'RNA helikaze', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 02 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:735463

Kovačević A. RNA helikaze [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2012 [cited 2025 January 02] Available at: https://urn.nsk.hr/urn:nbn:hr:217:735463

A. Kovačević, "RNA helikaze", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2012. Available at: https://urn.nsk.hr/urn:nbn:hr:217:735463

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Metadata
TitleRNA helikaze
Title (english)RNA helicases
AuthorAlen Kovačević
MentorIvana Ivančić Baće (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2012, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
RNA helikaze su visoko konzervirani enzimi prisutni u sve tri domene života te u nekim virusima. Uključeni su u sve korake RNA metabolizma od transkripcije do degradacije. Uspješno razdvajaju kraće dlRNA, RNA-DNA heteroduplekse, remodeliraju strukturu RNA te uklanjaju RNA iz RNP kompleksa. Sve te funkcije obavljaju u ovisnosti o vezanju i hidrolizi ATP-a. U ovom radu detaljnije su opisane eukariotske RNA helikaze s DEAD domenom. Karakteristika svih je posjedovanje dvije RecA proteinu slične domene s RNA i ATP veznim mjestima u srži enzima. Na primjeru eIF4A i Dbp5 pokazano je kako ovi visoko konzervirani enzimi u suradnji s drugim proteinima mogu obavljati vrlo različite uloge kao što su inicijacija translacije te transport mRNA iz jezgre u citoplazmu.
Abstract (english)
RNA helicases are highly conserved enzymes abundant in all three life domains and some viruses. These enzymes participate in all stages of RNA metabolism from transcription to degradation and are very effective in unwinding short dsRNAs, RNA-DNA heteroduplexes, remodeling RNA structure and removing RNAs from RNP complexes. All these functions are done in an ATP-dependent fashion. In this work, eucaryotic DEAD box RNA helicases are described in detail. Characteristic of all DEAD box proteins are two RecA-like domains which harbour RNA and ATP binding sites. These highly conserved enzymes in cooperation with other proteins can perform different functions such as the initiation of translation (eIF4A) and mRNA transport from nucleus to cytoplasm (Dbp5).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:735463
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-18 11:46:25