Utjecaj biljke konoplje (Cannabis sativa) na reproduktivni sustav kod sisavaca

undergraduate thesis

• Title (english): The influence of cannabis plant (Cannabis sativa) on reproductive system in mammals
• Author: Tanita Demir
• Mentor: Duje Lisičić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2018, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Zbog sve veće upotrebe biljke konoplje, potrebna su objektivna istraživanja kojima će se utvrditi njezin utjecaj na organizam. Uključivanjem u endokanabinoidni sustav reproduktivnih organa, kanabinoidi biljke konoplje mogu uzrokovati mnoge promjene u morfologiji i funkciji reproduktivnog sustava. Potvrđeno je da korištenje konoplje dovodi do kratkoročnih promjena u izlučivanju muških i ženskih spolnih hormona. Razvojem tolerancije na egzogene kanabinoide, količine spolnih hormona vraćaju se na početnu razinu. Unatoč tome, promjene u količini spolnih hormona imaju direktan učinak na organe reproduktivnog sustava. Abnormalni izgled i nefunkcionalnost spermija te histološke i biokemijske posljedice na testisima rezultat su djelovanja konoplje na muški reproduktivni sustav. Neuobičajeni rast maternice i mogući utjecaj na procese koji se odvijaju u jajovodu neki su od razloga kojima se potvrđuje toksičnost biljke konoplje za ženski reproduktivni sustav. Proučavanjem meta i mehanizama djelovanja konoplje na reproduktivni sustav, otvara se mogućnost za promjene u regulaciji reproduktivnih funkcija. Upravo zbog toga, daljnja istraživanja će omogućiti detaljnije spoznaje o utjecaju konoplje na organizam te potencijalno liječenje reproduktivnih poremećaja i neplodnosti.

Abstract (english)

Due to the increased use of cannabis plants, objective studies are needed to determine its impact on the organism. By incorporating into the endocannabinoid system of reproductive organs, cannabinoids of cannabis plants might cause many changes in the morphology and function of the reproductive system. It has been confirmed that the use of cannabis leads to short-term changes in the secretion of male and female sex hormones. By developing tolerance to exogenous cannabinoids, the number of sex hormones returns to the initial level. Despite this, the changes in the number of sex hormones have a direct effect on the organs of the reproductive system. Abnormal appearance and dysfunction of sperm cells, as well as the histological and biochemical effects on the testicles are the result of cannabis activity on the male reproductive system. The unusual growth of the uterus and the possible impact on the processes that take place in the oviduct are some of the reasons that confirms the toxicity of the cannabis plant for the female reproductive system. The study of the targets and mechanisms of cannabis effects on the reproductive system allows changes in the regulation of reproductive functions. Precisely for this reason, further research will enable more detailed understanding of the impact of cannabis on the body and possible new ways of treating the reproductive disorders and infertility.

• Keywords: konoplja; spolni hormoni
• Language: croatian
• URN:NBN: urn:nbn:hr:217:178284
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-10-10 09:31:41