Detekcija genetičkog kimerizma kod čovjeka

undergraduate thesis

• Title (english): Detecting genetic chimerism in humans
• Author: Ivana Keršić
• Mentor: Nenad Malenica (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2019, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Genetička kimera označava jedinku u čijem su organizmu prisutne populacije genetički
različitih stanica. Prvi slučajevi opisani su polovicom 20. stoljeća, a detekcija kimernih
pojedinaca pratila je poboljšanje i razvoj metoda njihove detekcije. Prvo je to bila serologija
krvnih grupa i primjećivanje morfoloških karakteristika, potom citogenetika, a sada su to
molekularne metode tipizacije. Danas je poznato nekoliko tipova kimerizma obzirom na
mehanizam nastanka, a neki oblici su relativno nedavno otkriveni upravo zbog napretka
tehnologije i metoda detekcije. Sve češće spominjanje kimera u kontekstu biomedicinskih
istraživanja i forenzičkih analiza potiče potrebu za daljnjim razvojem metoda detekcije kako bi
se omogućilo sustavno proučavanje i praćenje ove pojave kod čovjeka.

Abstract (english)

A genetic chimera means that an individual carries two genetically distinct lines within
its cells. The first cases were described in the middle of the 20th century and the detection of
such individuals closely followed advancement and development of new methods of detection.
First it was blood group serology and physical symptoms, then cytogenetic methods and now,
molecular typing methods. Today, several types of chimerism are known and all differ by their
mechanism of origin, some of which were relatively recently discovered because of the
mentioned technological advancement of new detection methods. Increasing interest for
chimerism in the context of biomedical research and forensic analysis encourages need for
further development of more precise detection methods to enable and systematic study and
tracking of this phenomena in humans.

• Keywords: kimerizam
• Language: croatian
• URN:NBN: urn:nbn:hr:217:437394
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-10-11 07:22:11