Logički krugovi u staničnom signaliziranju

undergraduate thesis

• Title (english): Logic circuits in cell signaling
• Author: Ivana Bolanča
• Mentor: Maja Matulić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2020-10-02, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Razvojem proteomike i genomike postalo je jasnije da su stanični procesi sačinjeni od velikog broja molekula koje mogu sudjelovati u više različitih procesa. Iz tog razloga su se istraživanja počela okretati od proučavanja zasebnih molekula k proučavanju čitavih mreža staničnih signalnih puteva. Teorija mreža je iznjedrila zaključak da su arhitektonski elementi svih kompleksnih mreža slični, bilo da je riječ o biološkim sustavima, tehnologiji ili društvenim mrežama. Takva univerzalnost je temelj ideje da su sve složene mreže vođene istim pravilima. Zahvaljujući ovoj ideji znanstvenici su počeli uočavati pravila koja reguliraju računalne mreže i u signalnim sustavima u stanici. Osnovnu jedinicu složene signalne mreže tj. čvorišta predstavljaju molekule, a usporedive su s logičkim sklopovima koji čine najosnovnije jedinice računala. Ovaj rad preko teorije logičkih sklopova objašnjava osnovne principe po kojima funkcioniraju već opisani signalni putevi, a koji su primjenjivi i prilikom opisivanja još uvijek neopisanih sustava te navodi moguće primjene ove teorije u području biotehnologije razvojem staničnih linija E. coli koje pokazauju dugoročno pamćenje, u ekologiji prilikom dizajniranja bakterija koje mogu detektirati okolišno onečišćenje i u medicini gdje mogu pomoći u selektivnom uklanjanju malignih stanica.

Abstract (english)

Advancement in the fields of proteomics and genomics made it obviously clear that most biological characteristics arise from complex interactions of numerous molecular constituents inside a cell. Research that followed this advancement was no longer based on studying individual molecules instead focusing on signaling networks. Network theory proposed that architectural features of complex networks were shared by all complex systems, such as molecular networks, computer chips and social networks. This universality was a key idea behind the usage of well described logic circuits in characterizing signaling pathways. Basic components of complex signaling networks are molecules that represent nodes in the network, similarly to logic gates that are the basic component of a computer network. This paper uses the theory behind logic circuits to describe principles that govern already established signaling pathways, which can later be used to describe the mechanism of unknown pathways as well as possible applications of this theory in fields of biotechnology when designing E. coli strains that show long term memory, in ecology when designing bacterial cells that can detect environmental pollution and medicine where it can be used to induce cell death exclusively in cancer cells.

• Keywords: staničnih signalni putevi
• Language: croatian
• URN:NBN: urn:nbn:hr:217:617685
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-10-07 11:10:14