Metabolizam tumora

undergraduate thesis

• Title (english): Tumor metabolism
• Author: Helena Hajpek
• Mentor: Inga Urlić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2020-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Tumori nastaju transformacijom stanica u tumorske stanice, a u pozadini toga nalaze se geni uključeni u regulaciju proliferacije, diferencijacije i preživljavanja. Na taj se način razvija deset značajki, specifičnih obilježja koja nisu svojstvena zdravim stanicama, a koje tumoru omogućavaju selektivnu prednost pred njima. Osim što se razlikuju od zdravog tkiva, tumorske se nakupine razlikuju i međusobno. Tumor, kao kompleksna tvorba nastala iz prvotno zdravog tkiva, uz ostale karakteristike dijeli s njime i zajedničke značajke metabolizma. Međutim, tumor razvija i neke svoje metaboličke osobitosti koje su predstavljene kroz ovaj seminarski rad. Među njima je temeljna značajka Warburgov efekt i njegove dobrobiti za tumor i tumorske stanice, a zatim i snabdijevanje energijom uz pomoć alternativnih načina dobivanja metabolita te osiguravanje sirovina za specifične potrebe tumora kroz vlastitu biosintezu. Dan je i kratak pregled mogućih terapija usmjerenih na korake i substrate tumorskog metabolizma. Jedan od puteva pronalaska i osmišljavanja što učinkovitije terapije sa što manje negativnih posljedica svakako je i istraživanje metaboličkih osobitosti tumora i terapija kojima su te osobitosti meta.

Abstract (english)

Tumors are formed by the transformation of cells into tumor cells, in the background of which are genes involved in the regulation of proliferation, differentiation and survival. In this way, ten features are developed, specific traits that are not characteristic of healthy cells, and which give the tumor a selective advantage over them. In addition to differing from healthy tissue, tumor clusters also differ from each other. The tumor, as a complex formation formed from originally healthy tissue, shares with it other common features and common features of metabolism. However, the tumor also develops some of its metabolic features which are presented through this seminar paper. Among them, the fundamental feature is the Warburg effect and its benefits for a tumor and tumor cells, and then the supply of energy through alternative methods of obtaining metabolites and providing raw materials for specific tumor needs through its own biosynthesis. A brief overview of possible therapies focused on the steps and substrates of tumor metabolism is also given. One of the ways to find and design the most effective therapy with as few negative consequences as possible is certainly the research of the metabolic characteristics of tumors and therapies that target these characteristics.

• Keywords: tumori
• Language: croatian
• URN:NBN: urn:nbn:hr:217:179755
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-10-20 09:51:06