Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja

master's thesis

• Title (english): High resolution mass spectrometric analysis of loratadine- cyclodextrine inclusion complexes
• Author: Ana-Emina Živko
• Mentor: Nives Galić (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Željka Soldin (član povjerenstva)
• Committee member: Jasmina Rokov Plavec (član povjerenstva)
• Committee member: Iva Juranović Cindrić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2021-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Inkluzijski kompleksi, nastali uslijed nekovalentnih interakcija između molekule domaćina i molekule gosta, rješenje su problema slabo topljivih lijekova. Kompleksiranje lijeka, zarobljenog u hidrofobnoj šupljini molekule domaćina, poboljšava njegova fizikalno-kemijska svojstva poput topljivosti i biodostupnosti. β-ciklodekstrin i njegov nasumično metilirani derivat izabrani su kao molekule domaćini, dok je molekula gost loratadin, lijek korišten u liječenju alergijskih poremećaja. Nastali inkluzijski kompleksi, također i spojevi koji ih grade, analizirani su hibridnim spektrometrom masa s kvadrupolom i analizatorom vremena leta. Tandemna spektrometrija masa provedena je nad izabranim ionima te je na temelju dobivenih rezultata predložen fragmentacijski put analiziranih spojeva. Korištena ionizacijska tehnika je elektroraspršenje, a spektri masa snimljeni su u pozitivnom i negativnom načinu snimanja.

Abstract (english)

Inclusion complexes, formed by noncovalent interactions between host molecule and guest molecule, are the solution of the problem of poorly soluble drugs. Encapsulation of the drugs in the hidrophobic cavity of the host molecule improves its physico-chemical properties, such as solubility and bioavailability. β-cyclodextrin and its randomly methylated derivative were selected as host molecules, while the guest molecule was the drug loratadine, used in the treatment of allergic disorders. Inclusion complexes, as well as the coumpounds that form them, were analyzed by a hibrid mass spectrometer with a quadrupole and a time-of-flight analyzer. Tandem mass spectrometry was performed on the selected ions and the fragmentation pathway of the analyzed compounds was proposed based on the obtained results. Electrospray was used as the ionization technique, and the mass spectra were recorded in positive and negative mode.

• Keywords: β-ciklodekstrin; elektroraspršenje; inkluzijski kompleks; loratadin; spektrometrija masa
• Keywords (english): β-cyclodextrine; electrospray; inclusion complexes; loratadine; mass spectrometry
• Language: croatian
• URN:NBN: urn:nbn:hr:217:159242
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2023-09-13
• Created on: 2021-09-15 07:48:13