Neurobiološka podloga opsesivno-kompulzivnog poremećaja

undergraduate thesis

• Title (english): The neurobiological basis of obsessive-compulsive disorder
• Author: Ana Sever
• Mentor: Dubravka Hranilović (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2021-09-01, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Opsesivno-kompulzivni poremećaj (OKP) karakterizira postojanje opsesija - prodornih i ponavljajućih misli, slika ili impulsa koje je nemoguće kontrolirati, te kompulzija - ponašanja koja izviru iz njih kako bi ublažile nelagodu proizišlu iz opsesija. Opsesije izazivaju anksioznost koje se osoba ne može lako riješiti. Zbog toga često vrše radnje koje se karakteriziraju kao ritualističke, a služe ublažavanju tog osjećaja. U početku je bilo teško proniknuti u biološku podlogu ovog poremećaja, jer su se dijagnostičke metode i metode liječenja tada još usavršavale. Prva istraživanja OKP-a su ukazivala na ulogu serotonina u simptomatici poremećaja te se regulacija serotoninskih sustava dugo koristila kao efektivna terapija.. Danas je pažnja okrenuta prema aktivnosti dopaminskih i glutamatnih sustava. Istraživanja dopaminskih sustava posebno su zanimljiva zbog uloge bazalnih ganglija u procesiranju misli i donošenju odluka Pretpostavlja se da prijenos glutamata, najzastupljenijeg neurotransmitera u ljudskom središnjem živčanom sustavu, uvelike utječe na razvoj simptoma OKP-a, prvenstveno zbog njegove poremećene aktivnosti u CSTC-krugu.

Abstract (english)

Obsessive-compulsive disorder (OCD) is a psychological disorder characterized by the presence of prevalent, often debilitating thoughts called obsessions. Those kinds of thoughts often evoke a feeling of anxiety that does not wash away easily, and is usually calmed by repeating certain actions in an almost ritualistic fashion. Those ritualistic actions are called compulsions and serve as a safe harbour for people to feel at ease. First insights into the disorder implied the role of serotonergic neurotransmission in the ethiology of the disorder, establishing treatments focused solely on that certain impairment. Other than that, it was hard to elucidate the root cause of the disorder, because effective methods and technologies in neurological research were yet to be perfected. Research into dopaminergic neurotransmission proved to be fruitful, especially considering the role of the basal ganglia in thought processing and decision making. Nowadays, glutamate is tought to be the main arbitrator of OCD symptom causaluty and severity, considering its involvement in the activity of the CSTC circuitry.

• Keywords: opsesije; kompulzije; CSTC; serotonin; dopamin; glutamat
• Keywords (english): obsessions; compulsions; CSTC; serotonin; dopamine; glutamate
• Language: croatian
• URN:NBN: urn:nbn:hr:217:047520
• Study programme: Title: Ecology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-09-15 13:34:01