Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model

Znanstveni rad - Izvorni znanstveni rad

• Autor: Marta Nowakowska
• Autor: Marie Jakešová
• Autor: Tony Schmidt
• Autor: Aleksandar Opančar
• Autor: Mathias Polz
• Autor: Robert Reimer
• Autor: Julia Fuchs
• Autor: Silke Patz
• Autor: Daniel Ziesel
• Autor: Susanne Scheruebel
• Autor: Karin Kornmueller
• Autor: Theresa Rienmüller
• Autor: Vedran Đerek
• Autor: Eric D. Głowacki
• Autor: Rainer Schindl
• Autor: Muammer Üçal
• Autorova ustanova: Sveučilište u Zagrebu; Prirodoslovno-matematički fakultet; (Fizički odsjek)
• Znanstveno / umjetničko područje, polje i grana: PRIRODNE ZNANOSTI; Fizika

Sažetak (engleski)

Neurostimulation employing photoactive organic semiconductors offers an appealing alternative to conventional techniques, enabling targeted action and wireless control through light. In this study, organic electrolytic photocapacitors (OEPC) are employed to investigate the effects of light‐controlled electric stimulation on neuronal networks in vitro and in vivo. The interactions between the devices and biological systems are characterized. Stimulation of primary rat cortical neurons results in an elevated expression of c‐Fos within a mature neuronal network. OEPC implantation for three weeks and subsequent stimulation of the somatosensory cortex leads to an increase of c‐Fos in neurons at the stimulation site and in connected brain regions (entorhinal cortex, hippocampus), both in the ipsi‐ and contralateral hemispheres. Reactivity of glial and immune cells after semi‐chronic implantation of OEPC in the rat brain is comparable to that of surgical controls, indicating minimal foreign body response. Device functionality is further substantiated through retained charging dynamics following explantation. OEPC‐based, light‐controlled electric stimulation has a significant impact on neural responsiveness. The absence of detrimental effects on both the brain and device encourages further use of OEPC as cortical implants. These findings highlight its potential as a novel mode of neurostimulation and instigate further exploration into applications in fundamental neuroscience.

• Ključne riječi (engleski): bioelectronics; cortical stimulation; c-Fos; excitability; immunohistochemistry; organic semiconductors; wireless stimulation R
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Advanced Healthcare Materials
• Brojčani podaci: vol. 2024, 2401303
• p-ISSN: 2192-2640
• e-ISSN: 2192-2659
• DOI: https://doi.org/10.1002/adhm.202401303
• URN:NBN: urn:nbn:hr:217:512424
• Datum objave publikacije: 2024-08-13
• Projekt: Šifra: UIP-2019-04-1753; Naziv (hrvatski): Mikro i nano-strukture za 3D opto-bioelektroniku; Naziv (engleski): Micro- and nano-structures for 3D opto-bioelectronics; Kratica: 3Doptobio; Voditelj: Vedran Đerek; Pravna nadležnost: Hrvatska; Financijer: Hrvatska zaklada za znanost; Linija financiranja: Installation Research Projects
• Projekt: Šifra: KK.01.1.1.02.0013; Naziv (hrvatski): Centar za Napredna Istraživanja Kompleksnih Sustava; Naziv (engleski): Centre for Advanced Research of Complex Systems; Kratica: CeNIKS; Voditelj: Mihael Srđan Grbić; Pravna nadležnost: eu; Financijer: Europska komisija; Linija financiranja: European Regional Development Fund
• Projekt: Šifra: KK.01.1.1.01.0004; Naziv (hrvatski): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri; Naziv (engleski): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras; Kratica: QuantiXLie; Voditelj: Hrvoje Buljan; Pravna nadležnost: eu; Financijer: Europska komisija; Linija financiranja: European Regional Development Fund
• URL dokumenta: https://onlinelibrary.wiley.com/doi/10.1002/adhm.202401303
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Javna napomena: © 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Received: April 9, 2024. Revised: August 5, 2024. Published online: 13 August 2024.
• Datum i vrijeme pohrane: 2024-09-12 12:50:05