Attention modulates topology and dynamics of auditory sensory gating

Znanstveni rad - Izvorni znanstveni rad

• Autor: Sanja Josef Golubić; MBZ: 317715
• Autor: Miljenka-Jelena Jurašić; MBZ: 260304
• Autor: Ana Sušac; MBZ: 236434
• Autor: Ralph Huonker
• Autor: Theresa Götz
• Autor: Jens Haueisen
• Autorova ustanova: Sveučilište u Zagrebu; Prirodoslovno-matematički fakultet; (Fizički odsjek)
• Znanstveno / umjetničko područje, polje i grana: PRIRODNE ZNANOSTI; Fizika
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Temeljne medicinske znanosti

Sažetak (engleski)

This work challenges the widely accepted model of sensory gating as a preattention inhibitory process by investigating whether attention directed at the second tone (S2) within a paired‐click paradigm could affect gating at the cortical level. We utilized magnetoencephalography, magnetic resonance imaging and spatio‐temporal source localization to compare the cortical dynamics underlying gating responses across two conditions (passive and attention) in 19 healthy subjects. Source localization results reaffirmed the existence of a fast processing pathway between the prefrontal cortex (PFC) and bilateral superior temporal gyri (STG) that underlies the auditory gating process. STG source dynamics comprised two gating sub‐components, Mb1 and Mb2, both of which showed significant gating suppression (>51%). The attention directed to the S2 tone changed the gating network topology by switching the prefrontal generator from a dorsolateral location, which was active in the passive condition (18/19), to a medial location, active in the attention condition (19/19). Enhanced responses to the attended stimulus caused a significant reduction in gating suppression in both STG gating components (>50%). Our results demonstrate that attention not only modulates sensory gating dynamics, but also exerts topological rerouting of information processing within the PFC. The present data, suggesting that the cortical levels of early sensory processing are subject to top‐down influences, change the current view of gating as a purely automatic bottom‐up process.

• Ključne riječi (engleski): attention; auditory gating generators; auditory sensory gating; dorsolateral prefrontal cortex; gating network; gating stream; magnetoencephalography; medial prefrontal cortex; neuroimaging; paired-click paradigm; sensory pathways
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Human Brain Mapping
• Brojčani podaci: vol. 40, br. 10, str. 2981-2994
• p-ISSN: 1065-9471
• e-ISSN: 1097-0193
• DOI: https://doi.org/10.1002/hbm.24573
• URN:NBN: urn:nbn:hr:217:707113
• Datum objave publikacije: 2019
• URL dokumenta: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24573
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Javna napomena: Received: 13 July 2018. Revised: 11 February 2019. Accepted: 6 March 2019. First published: 18 March 2019.
• Datum i vrijeme pohrane: 2020-08-18 18:21:57