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An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules
Genes, 13 (2022), 11; 1929. https://doi.org/10.3390/genes13111929
Rosandić, Marija; Vlahović, Ines; Pilaš, Ivan; Glunčić, Matko; Paar, Vladimir

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Rosandić, M., Vlahović, I., Pilaš, I., Glunčić, M. i Paar, V. (2022). An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules. Genes, 13. (11). doi: 10.3390/genes13111929

Rosandić, Marija, et al. "An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules." Genes, vol. 13, br. 11, 2022. https://doi.org/10.3390/genes13111929

Rosandić, Marija, Ines Vlahović, Ivan Pilaš, Matko Glunčić i Vladimir Paar. "An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules." Genes 13, br. 11 (2022). https://doi.org/10.3390/genes13111929

Rosandić, M., et al. (2022) 'An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules', Genes, 13(11). doi: 10.3390/genes13111929

Rosandić M, Vlahović I, Pilaš I, Glunčić M, Paar V. An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules. Genes [Internet]. 23.10.2022. [pristupljeno 24.12.2024.];13(11). doi: 10.3390/genes13111929

M. Rosandić, I. Vlahović, I. Pilaš, M. Glunčić i V. Paar, "An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules", Genes, vol. 13, br. 11, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:175472. [Citirano: 24.12.2024.]

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Naslov (engleski)An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules
AutorMarija Rosandić
AutorInes Vlahović
AutorIvan Pilaš
AutorMatko Glunčić
AutorVladimir Paar
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Sažetak (engleski)
In this article, we show that mono/oligonucleotide quadruplets, as basic structures of DNA, along with our classification of trinucleotides, disclose an organization of genomes based on purine–pyrimidine symmetry. Moreover, the structure and stability of DNA are influenced by the Watson–Crick pairing and the natural law of DNA creation and conservation, according to which the same mono- or oligonucleotide insertion must be inserted simultaneously into both strands of DNA. Taken together, they lead to quadruplets with central mirror symmetry and bidirectional DNA strand orientation and are incorporated into Chargaff’s second parity rule (CSPR). Performing our quadruplet frequency analysis of all human chromosomes and of Neuroblastoma BreakPoint Family (NBPF) genes, which code Olduvai protein domains in the human genome, we show that the coding part of DNA violates CSPR. This may shed new light and give rise to a novel hypothesis on DNA creation and its evolution. In this framework, the logarithmic relationship between oligonucleotide order and minimal DNA sequence length, to establish the validity of CSPR, automatically follows from the quadruplet structure of the genomic sequence. The problem of the violation of CSPR in rare symbionts is discussed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 13, br. 11, 1929
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes13111929
URN:NBNurn:nbn:hr:217:175472
Datum objave publikacije2022-10-23
ProjektŠifra: IP-2019-04-2757
Naziv (hrvatski): Varijante u repetitivnim strukturama višeg reda u centromernim i NBPF dijelovima genoma čovjeka i viših primata
Naziv (engleski): Variants in higher order repeat structures in centromeric and NBPF regions of human and higher primates genomes
Kratica: HORVAR
Voditelj: Matko Glunčić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/2073-4425/13/11/1929
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomena© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Received: 18 September 2022. Accepted: 17 October 2022. Published: 23 October 2022.
Datum i vrijeme pohrane2024-08-23 09:39:05