prikaz prve stranice dokumenta Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly
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Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly
International Journal of Molecular Sciences, 25 (2024), 14; 7596. https://doi.org/10.3390/ijms25147596
Glunčić, Matko; Vlahović, Ines; Rosandić, Marija; Paar, Vladimir

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Glunčić, M., Vlahović, I., Rosandić, M. i Paar, V. (2024). Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly. International Journal of Molecular Sciences, 25. (14). doi: 10.3390/ijms25147596

Glunčić, Matko, et al. "Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly." International Journal of Molecular Sciences, vol. 25, br. 14, 2024. https://doi.org/10.3390/ijms25147596

Glunčić, Matko, Ines Vlahović, Marija Rosandić i Vladimir Paar. "Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly." International Journal of Molecular Sciences 25, br. 14 (2024). https://doi.org/10.3390/ijms25147596

Glunčić, M., et al. (2024) 'Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly', International Journal of Molecular Sciences, 25(14). doi: 10.3390/ijms25147596

Glunčić M, Vlahović I, Rosandić M, Paar V. Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly. International Journal of Molecular Sciences [Internet]. 11.07.2024. [pristupljeno 13.09.2024.];25(14). doi: 10.3390/ijms25147596

M. Glunčić, I. Vlahović, M. Rosandić i V. Paar, "Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly", International Journal of Molecular Sciences, vol. 25, br. 14, Srpanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:458515. [Citirano: 13.09.2024.]

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Naslov (engleski)Novel Cascade Alpha Satellite HORs in Orangutan Chromosome 13 Assembly: Discovery of the 59mer HOR—The largest Unit in Primates—And the Missing Triplet 45/27/18 HOR in Human T2T-CHM13v2.0 Assembly
AutorMatko Glunčić
AutorInes Vlahović
AutorMarija Rosandić
AutorVladimir Paar
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Sažetak (engleski)
From the recent genome assembly NHGRI_mPonAbe1-v2.0_NCBI (GCF_028885655.2) of orangutan chromosome 13, we computed the precise alpha satellite higher-order repeat (HOR) structure using the novel high-precision GRM2023 algorithm with Global Repeat Map (GRM) and Monomer Distance (MD) diagrams. This study rigorously identified alpha satellite HORs in the centromere of orangutan chromosome 13, discovering a novel 59mer HOR—the longest HOR unit identified in any primate to date. Additionally, it revealed the first intertwined sequence of three HORs, 18mer/27mer/45mer HORs, with a common aligned “backbone” across all HOR copies. The major 7mer HOR exhibits a Willard’s-type canonical copy, although some segments of the array display significant irregularities. In contrast, the 14mer HOR forms a regular Willard’s-type HOR array. Surprisingly, the GRM2023 high-precision analysis of chromosome 13 of human genome assembly T2T-CHM13v2.0 reveals the presence of only a 7mer HOR, despite both the orangutan and human genome assemblies being derived from whole genome shotgun sequences.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 14, 7596
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25147596
URN:NBNurn:nbn:hr:217:458515
Datum objave publikacije2024-07-11
ProjektŠifra: IP-2019-04-2757
Naziv (hrvatski): Varijante u repetitivnim strukturama višeg reda u centromernim i NBPF dijelovima genoma čovjeka i viših primata
Naziv (engleski): Variants in higher order repeat structures in centromeric and NBPF regions of human and higher primates genomes
Kratica: HORVAR
Voditelj: Matko Glunčić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/1422-0067/25/14/7596
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomena© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Submission received: 20 June 2024. Revised: 5 July 2024. Accepted: 9 July 2024. Published: 11 July 2024.
Datum i vrijeme pohrane2024-09-12 19:29:32