Mitotic spindle: lessons from theoretical modeling

Znanstveni rad - Pregledni rad

• Autor: Iva M. Tolić
• Autor: Nenad Pavin
• Autorova ustanova: Sveučilište u Zagrebu; Prirodoslovno-matematički fakultet; (Fizički odsjek)
• Znanstveno / umjetničko područje, polje i grana: PRIRODNE ZNANOSTI; Fizika

Sažetak (engleski)

Cell biology is immensely complex. To understand how cells work, we try to find patterns and suggest hypotheses to identify underlying mechanisms. However, it is not always easy to create a coherent picture from a huge amount of experimental data on biological systems, where the main players have multiple interactions or act in redundant pathways. In such situations, when a hypothesis does not lead to a conclusion in a direct way, theoretical modeling is a powerful tool because it allows us to formulate hypotheses in a quantitative manner and understand their consequences. A successful model should not only reproduce the basic features of the system but also provide exciting predictions, motivating new experiments. Much is learned when a model based on generally accepted knowledge cannot explain experiments of interest, as this indicates that the original hypothesis needs to be revised. In this Perspective, we discuss these points using our experiences in combining experiments with theory in the field of mitotic spindle mechanics.

• Ključne riječi (engleski): mitotic spindle , microtubules; kinetochores; kinetochore fibers; bridging fibers; kinesins; forces; laser ablation; microneedle; theory; modeling
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Molecular Biology of the Cell
• Brojčani podaci: vol. 32, br. 3, str. 218-222
• p-ISSN: 1059-1524
• e-ISSN: 1939-4586
• DOI: https://doi.org/10.1091/mbc.E20-05-0335
• URN:NBN: urn:nbn:hr:217:224215
• Datum objave publikacije: 2021-02-01
• Projekt: Šifra: PZS-2019-02-7653; Naziv (hrvatski): Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena; Naziv (engleski): Mechanisms of microtubule bundle formation required for spindle maturation; Kratica: SpindleForm; Voditelj: Iva Marija Tolić; Pravna nadležnost: Hrvatska; Financijer: Hrvatska zaklada za znanost; Linija financiranja: Programme Research Cooperability
• Projekt: Šifra: IP-2019-04-5967; Naziv (hrvatski): Ravnoteža sila i momenta sila u diobenom vretenu; Naziv (engleski): Balance of forces and torques in the mitotic spindle; Kratica: SpindleForceBalance; Voditelj: Nenad Pavin; Pravna nadležnost: Hrvatska; Financijer: Hrvatska zaklada za znanost; Linija financiranja: Research Projects
• Projekt: Šifra: KK.01.1.1.01.0004; Naziv (hrvatski): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri; Naziv (engleski): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras; Kratica: QuantiXLie; Voditelj: Hrvoje Buljan; Pravna nadležnost: eu; Financijer: Europska komisija; Linija financiranja: European Regional Development Fund
• URL dokumenta: https://www.molbiolcell.org/doi/10.1091/mbc.E20-05-0335
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Javna napomena: © 2021 Tolić and Pavin. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is avail able to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). Received: Oct 13, 2020. Revised: Nov 23, 2020. Accepted: Nov 24, 2020.
• Datum i vrijeme pohrane: 2024-09-25 21:06:25