prikaz prve stranice dokumenta Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
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Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
Scientific Reports, 6 (2016); 25736. https://doi.org/10.1038/srep25736
Cojoc, Gheorghe; Ana-Maria, Florescu; Krull, Alexander; Anna H., Klemm; Pavin, Nenad; Jülicher, Frank; Tolić, Iva Marija

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Cojoc, G., Ana Maria, F., Krull, A., Anna H., K., Pavin, N., Jülicher, F. i Tolić, I. M. (2016). Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I. Scientific Reports, 6.. doi: 10.1038/srep25736

Cojoc, Gheorghe, et al. "Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I." Scientific Reports, vol. 6, 2016. https://doi.org/10.1038/srep25736

Cojoc, Gheorghe, Florescu Ana Maria, Alexander Krull, Klemm Anna H., Nenad Pavin, Frank Jülicher i Iva Marija Tolić. "Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I." Scientific Reports 6 (2016). https://doi.org/10.1038/srep25736

Cojoc, G., et al. (2016) 'Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I', Scientific Reports, 6. doi: 10.1038/srep25736

Cojoc G, Ana Maria F, Krull A, Anna H. K, Pavin N, Jülicher F, i sur.. Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I. Scientific Reports [Internet]. 2016. [pristupljeno 30.10.2024.];6. doi: 10.1038/srep25736

G. Cojoc, et al., "Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I", Scientific Reports, vol. 6, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:824945. [Citirano: 30.10.2024.]

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Naslov (engleski)Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
AutorGheorghe Cojoc
AutorFlorescu Ana-Maria
AutorAlexander Krull
AutorKlemm Anna H.
AutorNenad Pavin
MBZ: 204800
AutorFrank Jülicher
AutorIva Marija Tolić
MBZ: 260543
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
Kinetochores are protein complexes on the chromosomes, whose function as linkers between spindle microtubules and chromosomes is crucial for proper cell division. The mechanisms that facilitate kinetochore capture by microtubules are still unclear. In the present study, we combine experiments and theory to explore the mechanisms of kinetochore capture at the onset of meiosis I in fission yeast. We show that kinetochores on homologous chromosomes move together, microtubules are dynamic and pivot around the spindle pole, and the average capture time is 3-4 minutes. Our theory describes paired kinetochores on homologous chromosomes as a single object, as well as angular movement of microtubules and their dynamics. For the experimentally measured parameters, the model reproduces the measured capture kinetics and shows that the paired configuration of kinetochores accelerates capture, whereas microtubule pivoting and dynamics have a smaller contribution. Kinetochore pairing may be a general feature that increases capture efficiency in meiotic cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 6, 25736
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/srep25736
URN:NBNurn:nbn:hr:217:824945
Datum objave publikacije2016
URL dokumentahttps://www.nature.com/articles/srep25736
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomena© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/. Received: 28 January 2016. Accepted: 21 April 2016. Published: 11 May 2016.
Datum i vrijeme pohrane2020-02-23 14:37:35