prikaz prve stranice dokumenta Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
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Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
Developmental cell, 43 (2017), 1; 11-23. https://doi.org/10.1016/j.devcel.2017.09.010
Vukušić, Kruno; Buđa, Renata; Bosilj, Agneza; Milas, Ana; Pavin, Nenad; Tolić, Iva Marija

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Vukušić, K., Buđa, R., Bosilj, A., Milas, A., Pavin, N. i Tolić, I. M. (2017). Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes. Developmental cell, 43. (1), 11-23. doi: 10.1016/j.devcel.2017.09.010

Vukušić, Kruno, et al. "Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes." Developmental cell, vol. 43, br. 1, 2017, str. 11-23. https://doi.org/10.1016/j.devcel.2017.09.010

Vukušić, Kruno, Renata Buđa, Agneza Bosilj, Ana Milas, Nenad Pavin i Iva Marija Tolić. "Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes." Developmental cell 43, br. 1 (2017): 11-23. https://doi.org/10.1016/j.devcel.2017.09.010

Vukušić, K., et al. (2017) 'Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes', Developmental cell, 43(1), str. 11-23. doi: 10.1016/j.devcel.2017.09.010

Vukušić K, Buđa R, Bosilj A, Milas A, Pavin N, Tolić IM. Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes. Developmental cell [Internet]. 2017. [pristupljeno 14.11.2024.];43(1):11-23. doi: 10.1016/j.devcel.2017.09.010

K. Vukušić, R. Buđa, A. Bosilj, A. Milas, N. Pavin i I. M. Tolić, "Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes", Developmental cell, vol. 43, br. 1, str. 11-23, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:599330. [Citirano: 14.11.2024.]

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Podaci o radu
Naslov (engleski)Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
AutorKruno Vukušić
AutorRenata Buđa
AutorAgneza Bosilj
MBZ: 349215
AutorAna Milas
AutorNenad Pavin
MBZ: 204800
AutorIva Marija Tolić
MBZ: 260543
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinetochores. What forces drive chromosome segregation in anaphase remains a central question. The current model for anaphase in human cells includes shortening of kinetochore fibers and separation of spindle poles. Both processes require kinetochores to be linked with the poles. Here we show, by combining laser ablation, photoactivation, and theoretical modeling, that kinetochores can separate without any attachment to one spindle pole. This separation requires the bridging fiber, a microtubule bundle that connects sister kinetochore fibers. Bridging fiber microtubules in intact spindles slide apart with kinetochore fibers, indicating strong crosslinks between them. We conclude that sliding of microtubules within the bridging fibers drives pole separation and pushes kinetochore fibers poleward by the friction of passive crosslinks between these fibers. Thus, sliding within the bridging fiber works together with the shortening of kinetochore fibers to segregate chromosomes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDevelopmental cell
Brojčani podacivol. 43, br. 1, str. 11-23
p-ISSN1534-5807
DOIhttps://doi.org/10.1016/j.devcel.2017.09.010
URN:NBNurn:nbn:hr:217:599330
Datum objave publikacije2017
URL dokumentahttps://www.sciencedirect.com/science/article/pii/S1534580717307335
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Javna napomena© 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). This work was funded by the European Research Council (ERC, GA number 647077). Published 9 October 2017.
Datum i vrijeme pohrane2020-02-28 10:39:36