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The mitotic spindle is chiral due to torques within microtubule bundles
Nature Communications, 9 (2018); 3571. https://doi.org/10.1038/s41467-018-06005-7
Novak, Maja; Polak, Bruno; Simunić, Juraj; Boban, Zvonimir; Kuzmić, Barbara; Thomae, Andreas W; Tolić, Iva Marija; Pavin, Nenad

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Novak, M., Polak, B., Simunić, J., Boban, Z., Kuzmić, B., Thomae, A. W. ... Pavin, N. (2018). The mitotic spindle is chiral due to torques within microtubule bundles. Nature Communications, 9.. doi: 10.1038/s41467-018-06005-7

Novak, Maja, et al. "The mitotic spindle is chiral due to torques within microtubule bundles." Nature Communications, vol. 9, 2018. https://doi.org/10.1038/s41467-018-06005-7

Novak, Maja, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W Thomae, Iva Marija Tolić i Nenad Pavin. "The mitotic spindle is chiral due to torques within microtubule bundles." Nature Communications 9 (2018). https://doi.org/10.1038/s41467-018-06005-7

Novak, M., et al. (2018) 'The mitotic spindle is chiral due to torques within microtubule bundles', Nature Communications, 9. doi: 10.1038/s41467-018-06005-7

Novak M, Polak B, Simunić J, Boban Z, Kuzmić B, Thomae AW, i sur.. The mitotic spindle is chiral due to torques within microtubule bundles. Nature Communications [Internet]. 2018. [pristupljeno 17.04.2024.];9. doi: 10.1038/s41467-018-06005-7

M. Novak, et al., "The mitotic spindle is chiral due to torques within microtubule bundles", Nature Communications, vol. 9, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:446605. [Citirano: 17.04.2024.]

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Podaci o radu
Naslov (engleski)The mitotic spindle is chiral due to torques within microtubule bundles
AutorMaja Novak
MBZ: 344456
AutorBruno Polak
AutorJuraj Simunić
MBZ: 322860
AutorZvonimir Boban
AutorBarbara Kuzmić
MBZ: 362291
AutorAndreas W Thomae
AutorIva Marija Tolić
MBZ: 260543
AutorNenad Pavin
MBZ: 204800
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
Mitosis relies on forces generated in the spindle, a micro- machine composed of microtubules and associated proteins. Forces are required for the congression of chromosomes to the metaphase plate and their separation in anaphase. However, besides forces, torques may exist in the spindle, yet they have not been investigated. Here we show that the spindle is chiral. Chirality is evident from the finding that microtubule bundles in human spindles follow a left-handed helical path, which cannot be explained by forces but rather by torques. Kinesin-5 (Kif11/Eg5) inactivation abolishes spindle chirality. Our theoretical model predicts that bending and twisting moments may generate curved shapes of bundles. We found that bundles turn by about −2 deg µm−1 around the spindle axis, which we explain by a twisting moment of roughly −10 pNµm. We conclude that torques, in addition to forces, exist in the spindle and determine its chiral architecture.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 9, 3571
p-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-018-06005-7
URN:NBNurn:nbn:hr:217:446605
Datum objave publikacije2018
URL dokumentahttps://www.nature.com/articles/s41467-018-06005-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomena© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. Published: 03 September 2018.
Datum i vrijeme pohrane2020-03-01 12:27:14