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Pivot-and-bond model explains microtubule bundle formation
Physical Review E, 100 (2019), 1; 012403. https://doi.org/10.1103/PhysRevE.100.012403
Prelogović, Marcel; Winters, Lora; Milas, Ana; Tolić, Iva; Pavin, Nenad

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Prelogović, M., Winters, L., Milas, A., Tolić, I. i Pavin, N. (2019). Pivot-and-bond model explains microtubule bundle formation. Physical Review E, 100. (1). doi: 10.1103/PhysRevE.100.012403

Prelogović, Marcel, et al. "Pivot-and-bond model explains microtubule bundle formation." Physical Review E, vol. 100, br. 1, 2019. https://doi.org/10.1103/PhysRevE.100.012403

Prelogović, Marcel, Lora Winters, Ana Milas, Iva Tolić i Nenad Pavin. "Pivot-and-bond model explains microtubule bundle formation." Physical Review E 100, br. 1 (2019). https://doi.org/10.1103/PhysRevE.100.012403

Prelogović, M., et al. (2019) 'Pivot-and-bond model explains microtubule bundle formation', Physical Review E, 100(1). doi: 10.1103/PhysRevE.100.012403

Prelogović M, Winters L, Milas A, Tolić I, Pavin N. Pivot-and-bond model explains microtubule bundle formation. Physical Review E [Internet]. 2019. [pristupljeno 27.12.2024.];100(1). doi: 10.1103/PhysRevE.100.012403

M. Prelogović, L. Winters, A. Milas, I. Tolić i N. Pavin, "Pivot-and-bond model explains microtubule bundle formation", Physical Review E, vol. 100, br. 1, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:834769. [Citirano: 27.12.2024.]

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Podaci o radu
Naslov (engleski)Pivot-and-bond model explains microtubule bundle formation
AutorMarcel Prelogović
MBZ: 342476
AutorLora Winters
AutorAna Milas
AutorIva Tolić
AutorNenad Pavin
MBZ: 204800
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Sažetak (engleski)
During mitosis, microtubules form a spindle, which is responsible for proper segregation of the genetic material. A common structural element in a mitotic spindle is a parallel bundle, consisting of two or more microtubules growing from the same origin and held together by cross-linking proteins. An interesting question is what are the physical principles underlying the formation and stability of such microtubule bundles. Here we show, by introducing the pivot-and-bond model, that random angular movement of microtubules around the spindle pole and forces exerted by cross-linking proteins can explain the formation of microtubule bundles as observed in our experiments. The model predicts that stable parallel bundles can form in the presence of either passive crosslinkers or plus-end directed motors, but not minus-end directed motors. In the cases where bundles form, the time needed for their formation depends mainly on the concentration of cross-linking proteins and the angular diffusion of the microtubule. In conclusion, the angular motion drives the alignment of microtubules, which in turn allows the cross-linking proteins to connect the microtubules into a stable bundle.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPhysical Review E
Brojčani podacivol. 100, br. 1, 012403
p-ISSN2470-0045
e-ISSN2470-0053
DOIhttps://doi.org/10.1103/PhysRevE.100.012403
URN:NBNurn:nbn:hr:217:834769
Datum objave publikacije2019
URL dokumentahttps://journals.aps.org/pre/abstract/10.1103/PhysRevE.100.012403
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Javna napomena© 2019 American Physical Society. Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Received 18 April 2017. Revised 24 April 2019. Published 9 July 2019.
Datum i vrijeme pohrane2020-08-24 12:17:33