Mjerenje apsorbiranih doza u području izvan ciljnog volumena tijekom kraniospinalnog ozračivanja radioterapijskim tehnikama VMAT i 3D-CRT

master's thesis

• Title (english): Out-of-field measurements in craniospinal irradiations with 3D-CRT and VMAT radiotherapy
• Author: Ivan Veršić
• Mentor: Marija Majer (mentor)
• Mentor: Tomislav Bokulić (komentor)
• Committee member: Tomislav Bokulić (predsjednik povjerenstva)
• Committee member: Marija Majer (član povjerenstva)
• Committee member: Maja Planinić (član povjerenstva)
• Committee member: Mihael Makek (član povjerenstva)
• Committee member: Katarina Jeličić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Physics); Zagreb
• Defense date and country: 2021-09-21, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Physics

Abstract

U ovom radu su uspoređene mjerene i izračunate apsorbirane doze izvan ciljnog volumena u kraniospinalnom zračenju dvjema radioterapijskim tehnikama: trodimenzionalnom konformalnom radioterapijom (engl. three dimensional conformal radiotherapy, 3D-CRT) i volumno moduliranom lučnom terapijom (engl. volumetric modulated arc therapy, VMAT). Usporedba je napravljena na primjeru kraniospinalnog zračenja antropomorfnog fantoma koji predstavlja desetogodišnje dijete. Za obje su tehnike korišteni klinički prihvatljivi planovi zračenja za isti ciljni volumen. Apsorbirane doze u fantomu su mjerenje radiofotoluminiscentnim (RPL) dozimetrima i uspoređene za obje radioterapijske tehnike. Mjerene vrijednosti apsorbiranih doza uspoređene su i s vrijednostima koje daje sustav za izračun i optimizaciju raspodjele apsorbirane doze (engl. treatment planning system). Rezultati rada pokazuju bolje slaganje mjerenih i računalnih vrijednosti apsorbiranih doza za tehniku VMAT te da VMAT osigurava manju apsorbiranu dozu za većinu mjerenih organa izvan ciljnog volumena nego tehnika 3D-CRT.

Abstract (english)

In this diploma thesis, calculated and measured out-of-field apsorbed doses are compared for craniospinal irradiation with two radiotherapy techniques: three dimensional conformal radiotherapy (3D-CRT) and volumetric modulated arc therapy (VMAT). Comparison was made on an example of craniospinal irradiation of the anthropomorphic phantom which represents a ten year old child. For both techniques, clinically acceptable plan of irradiation was made for the same target volume. Apsorbed doses in phantom were measured with radiophotoluminescence (RPL) dosimeters and compared for both radiotherapy techniques. Measured values of apsorbed doses were also compared with values given by the treatment planning system. Results of this thesis show that VMAT technique offers better agreement of measured and predicted apsorbed doses and it also gives less apsorbed dose for most of the organs outside the target volume compared to 3D-CRT.

• Keywords: kraniospinalno ozračivanje; 3D-CRT; VMAT; apsorbirana doza; antropomorfni fantom; RPL dozimetar
• Keywords (english): craniospinal irradiation; 3D-CRT; VMAT; absorbed dose; anthropomorphic phantom; RPL dosimeter
• Language: croatian
• URN:NBN: urn:nbn:hr:217:357765
• Study programme: Title: Physics; specializations in: Education; Course: Education; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra edukacije fizike (magistar/magistra edukacije fizike)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-11-09 12:11:04