Analiza tragova polibromiranih difenil-etera u kućnoj prašini i ljudskome mlijeku radi procjene rizika za ljudsko zdravlje

doctoral thesis

• Title (english): Trace analysis of polybrominated diphenyl ethers in household dust and human milk for human health risk assessment
• Author: Karla Jagić
• Mentor: Darija Klinčić (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Irena Brčić Karačonji (član povjerenstva)
• Committee member: Ivan Senta (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2022-10-26, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry
• Universal decimal classification (UDC): 54 - Chemistry. Crystallography. Mineralogy

Abstract

Polibromirani difenil-eteri (PBDE) postojani su organski spojevi korišteni kao usporivači
gorenja. Karakteristična su zagađivala unutarnjih prostora, a nakupljaju se u kućnoj prašini, čija
je ingestija, uz prehranu, glavni put njihova unosa u ljude. Za dojenčad hranjenu ljudskim
mlijekom, ono predstavlja glavni izvor izloženosti. U ovom je radu primijenjena ekstrakcija
potpomognuta mikrovalovima za određivanje sedam spojeva PBDE u kućnoj prašini, a po prvi
put i u uzorcima ljudskog mlijeka, uz pažljivu optimizaciju uvjeta ekstrakcije i pročišćavanja.
Pročišćeni ekstrakti analizirani su plinskom kromatografijom uz detektor zahvata elektrona.
Analizom 30 uzoraka ljudskog mlijeka ispitanica i prašine iz njihovih kućanstava s područja
Zagreba i okolice dobivene su prve informacije o statusu onečišćenja ovim spojevima u
Hrvatskoj te parametrima koji potencijalno utječu na njihove razine. Detektirani maseni udjeli
spojeva PBDE bili su podjednaki onima u ostatku Europe, dok su na globalnoj razini među
nižima. Prema procijenjenim dnevnim unosima spojeva PBDE, zaključeno je da ne
predstavljaju rizik za zdravlje dojenčadi i majki na ovom području.

Abstract (english)

Polybrominated diphenyl ethers (PBDEs) are persistent organic compounds used as flame
retardants. They are typical indoor pollutants and accumulate in house dust, the ingestion of
which is the most important route of exposure for humans besides diet. For breastfed infants,
the main source of exposure is mother's milk. In this work, microwave-assisted extraction was
used for the analysis of seven PBDEs in house dust and, for the first time, in human milk, with
carefully optimized extraction conditions and clean-up. Purified extracts were analysed by gas
chromatography coupled to an electron capture detector. The analysis of house dust and human
milk samples from women (N = 30) living in these households in Zagreb and its surroundings
provided the first information on the level of contamination with these compounds in Croatia
and the parameters potentially affecting their levels. The determined mass fractions of PBDEs
are similar to the rest of Europe and among the lowest in the world. The estimated daily intakes
of PBDEs suggest that they do not pose a health risk to infants and mothers in the studied area.

• Keywords: bromirani usporivači gorenja; ekstrakcija potpomognuta mikrovalovima; kućna prašina; ljudsko mlijeko; polibromirani difenil-eteri; postojana organska zagađivala; procjena rizika
• Keywords (english): brominated flame retardants; house dust; human milk; microwave-assisted extraction; polybrominated diphenyl ethers; persistent organic pollutants; risk assessment
• Language: croatian
• URN:NBN: urn:nbn:hr:217:498740
• Promotion: 2022
• Study programme: Title: Doctoral study in chemistry; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
• Type of resource: Text
• Extent: 123 str. ; 30 cm
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2024-10-26
• Created on: 2022-11-02 10:25:05