Forsirana razgradnja loratadina i inkluzijskih kompleksa loratadina i ciklodekstrina

master's thesis

• Title (english): Forced degradation of loratadine and loratadine/cyclodextrin inclusion complexes
• Author: Ivana Prkić
• Mentor: Nives Galić (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Željka Soldin (član povjerenstva)
• Committee member: Davor Kovačević (član povjerenstva)
• Committee member: Iva Juranović Cindrić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2022-11-17, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Loratadin je antihistaminik, koji prema biofarmaceutskom klasifikacijskom sustavu spada u
skupinu lijekova slabe topljivosti. Međutim njegova topljivost, ali i stabilnost može se
poboljšati stvaranjem inkluzijskih kompleksa s ciklodekstrinima. Stabilnost lijekova od velike
je važnosti u farmaceutskoj industriji jer utječe na njihovu sigurnost i učinkovitost. Forsiranom
razgradnjom dobivaju se informacije o stabilnosti lijeka i razgradnim produktima koji nastaju.
U ovom radu istražen je utjecaj β-ciklodekstrina na stabilnost loratadina. Postotak razgradnje
loratadina određen je tekućinskom kromatografijom ultra visoke djelotvornosti. Uzorci s
uočenim potencijalnim razgradnim produktima analizirani su vezanim sustavom tekućinske
kromatografije i spektrometrije masa visokog razlučivanja. Na temelju MS i MS/MS spektara
predložene su strukture razgradnih produkata.

Abstract (english)

Loratadine is antihistamine that is categorized in Biopharmaceutics Classification System
as a poorly soluble drug. However, its solubility and stability can be improved by formation of
inclusion complexes with cyclodextrins. The stability of drugs is of great importance in the
pharmaceutical industry because it affects their safety and efficacy. Forced degradation
provides information on stability of drugs and resulting degradation products. In this work
effect of β-cyclodextrin on stability of loratadine was studied. Ultra-high performance liquid
chromatography was used to determine the percentage of degradation in each sample. Liquid
chromatography coupled to high resolution mass spectrometer was used on selected samples.
Structures of degradants and fragmentation pathways were proposed based on obtained results.

• Keywords: β-ciklodekstrin; forsirana razgradnja; inkluzijski kompleks; loratadin; spektrometrija masa
• Keywords (english): β-cyclodextrin; Forced degradation; Inclusion complex; Loratadine; Mass spectrometry
• Language: croatian
• URN:NBN: urn:nbn:hr:217:805592
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2024-11-17
• Created on: 2022-12-01 15:02:57