Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba

doctoral thesis

• Title (english): The role of brain derived neurotrophic factor in development of coronary heart disease in obese patients
• Author: Aleksandra Šustar
• Mentor: Nela Pivac (mentor); MBZ: 113176
• Committee member: Dubravka Švob Štrac (član povjerenstva)
• Committee member: Dubravka Hranilović (član povjerenstva)
• Committee member: Boris Brkljačić (član povjerenstva); MBZ: 175585
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2015, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 57 - Biological sciences. Physical anthropology. Biodiversity

Abstract

Moždani neurotrofni čimbenik (BDNF) je neutrofin s važnom ulogom u regulaciji tjelesne mase i pretilosti. Pretilost je važan čimbenik rizika za koronarnu bolest srca (KBS). Cilj je bio istražiti povezanost između KBS, pretilosti i koncentracije BDNF-a u plazmi i raspodjele genotipova Val66Met gena BDNF, te utjecaj rizičnih čimbenika za razvoj KBS i pretilosti, kod osoba s KBS i zdravih kontrolnih ispitanika. Koncentracija BDNF-a u plazmi bila je značajno niža kod osoba s KBS prema zdravim ispitanicima, ali se nije razlikovala između pretilih i nepretilih ispitanika, kao niti između nosioca različitih genotipova Val66Met gena BDNF. Raspodjela genotipova Val66Met gena BDNF bila je slična kod osoba s ili bez KBS i/ili pretilosti. Rizični čimbenici/pokazatelji za razvoj KBS bili su koncentracije BDNF-a, glukoze, HDL-kolesterola i opseg struka, a za pretilost samo opseg struka. Rezultati upućuju na ulogu BDNF-a u KBS i njegovu potencijalnu primjenu u dijagnostici KBS, no ne i pretilosti.

Abstract (english)

Brain derived neurotrophic factor (BDNF) is a neurotrophin with important role in regulation of body weight and obesity. Obesity is a substantial risk factor for coronary heart disease (CHD). Aim was to determine the association between CHD, obesity and plasma BDNF concentration and BDNF Val66Met genotype frequency, and the influence of risk factors for development of CHD and obesity, in subjects with CHD and healthy control subjects. Plasma BDNF concentration was significantly lower in CHD patients than in control subjects, but did not differ between obese and non-obese subjects, or between different BDNF Val66Met genotype carriers. BDNF Val66Met genotype frequency was similar in subjects with or without CHD and/or obesity. Risk factors/indicators for CHD were concentrations of BDNF, glucose, HDL-cholesterol and waist circumference, and for obesity only waist circumference. The results suggest the role of BDNF in CHD and its potential application in the diagnosis of CHD, but not in obesity.

• Keywords: moždani neurotrofni čimbenik (BDNF); polimorfizam Val66Met gena BDNF; koronarna bolest srca; pretilost; lipidne frakcije; rizični čimbenici
• Keywords (english): brain derived neurotrophic factor (BDNF); BDNF Val66Met polymorphism; coronary heart disease; obesity; lipid fractions; risk factors
• Language: croatian
• URN:NBN: urn:nbn:hr:217:056950
• Study programme: Title: Biology; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2017-05-17 11:22:49