Hidrazino - derivati aminokiselina u sintezi peptidomimetika

doctoral thesis

• Title (english): Synthesis of peptidomimetics comprising hydrazino - derivatives of amino acides
• Author: Josipa Suć
• Mentor: Ivanka Jerić (mentor)
• Committee member: Ines Primožič (predsjednik povjerenstva)
• Committee member: Ivanka Jerić (član povjerenstva)
• Committee member: Zdenko Hameršak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2016-07-07, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Organic Chemistry
• Universal decimal classification (UDC): 54 - Chemistry. Crystallography. Mineralogy

Abstract

Peptidi i proteini imaju ključnu ulogu u nizu bioloških i fizioloških procesa; međutim, njihova primjena kao terapeutika je ograničena slabom stabilnošću i biodostupnošću. Stoga je razvoj peptidomimetika, spojeva koji oponašaju strukturu i/ili funkciju proteina od velikog značaja za akademsku zajednicu i farmaceutsku industriju. Cilj istraživanja predloženih u okviru doktorske disertacije je priprava peptidomimetika korištenjem hidrazino-derivata -aminokiselina. Istraživanja će uključivati: razvoj metodologije za pripravu optički čistih hidrazino-derivata -aminokiselina te razvoj metodologije za pripravu hidrazino-peptidomimetika postupnom sintezom u otopini i primjenom u višekomponentnim reakcijama. Istraživanja bi trebala rezultirati optimiranim uvjetima priprave hidrazino-derivata -aminokiselina i hidrazino-peptidomimetika te potpuno novom skupinom peptidomimetika s ugrađenom hidrazino-jedinicom.

Abstract (english)

Peptides and proteins have a crucial role in a number of biological and physiological processes; however, their use as therapeutics is limited by poor stability and bioavailability. Therefore, the development of peptidomimetics, compounds that mimic structure and/or function of proteins is of great importance for the academic community and the pharmaceutical industry. The objective of the research proposed in this doctoral thesis is the preparation of peptidomimetics using hydrazino derivatives of -amino acids. Therefore, studies include: development of methodologies for the preparation of optically pure hydrazino derivatives of -amino acids; development of methodology for the preparation of hydrazino peptidomimetics by stepwise synthesis in solution and by multicomponent reactions. Expected results are: optimized conditions for the preparation of hydrazino derivatives of -amino acids and hydrazino peptidomimetics and a new class of peptidomimetics comprising hydrazino moiety. Item Type: Thesis (Doctoral thesis)

• Keywords: hidrazino-derivati -aminokiselina; hidrazino-depsipeptidi; hidrazino-peptidomimetici; višekomponentne reakcije
• Keywords (english): hydrazino derivatives of -amino acids; hydrazino depsipeptides; hydrazino peptidomimetics; multicomponent reactions
• Language: croatian
• URN:NBN: urn:nbn:hr:217:472032
• Study programme: Title: Doctoral study in chemistry; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
• Type of resource: Text
• Extent: 191 str. ; 30 cm
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-02-06 11:32:27