Povezanost poremećaja spavanja s polimorfizmom gena za serotoninski prijenosnik i koncentracijom trombocitnog serotonina u ispitanika s posttraumatskim stresnim poremećajem

master's thesis

• Title (english): The association of sleep disturbances with serotonin transporter gene polymorphism and platelet serotonin concentration in subjects with post-traumatic stress disorder
• Author: Eva Vigato
• Mentor: Dubravka Švob Štrac (mentor)
• Mentor: Julija Erhardt (mentor)
• Committee member: Julija Erhardt (predsjednik povjerenstva)
• Committee member: Željka Vidaković-Cifrek (član povjerenstva)
• Committee member: Jasna Lajtner (član povjerenstva)
• Committee member: Nataša Bauer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2017-07-18, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Post-traumatski stresni poremećaj (PTSP) je kompleksan psihijatrijski poremećaj koji se javlja nakon traumatskog iskustva. Poremećaji spavanja, poput noćnih mora i nesanice, jedno su od glavnih obilježja PTSP-a. Iako neurobiološka podloga PTSP-a nije potpuno jasna, ona uključuje kompleksne interakcije genetskih i okolišnih čimbenika. Serotoninski sustav radi svoje uloge u nadzoru raspoloženja, pobudljivosti i spavanja, važan je za razvoj simptoma PTSP-a. Cilj istraživanja bio je utvrditi moguću povezanost polimorfizma u genu za serotoninski prijenosnik i koncentracije trombocitnog serotonina s poremećajima spavanja u 393 hrvatskih ratnih veterana s PTSP-om. Genotipovi polimorfizma 5-HTTLPR bili su slično raspoređeni u veterana s PTSP-om i u kontrolnim ispitanicima. Raspodjela genotipova polimorfizma 5-HTTLPR bila je također slična u veterana s PTSP-om sa ili bez komorbidne depresije, dok je koncentracija trombocitnog serotonina bila niža u veterana s PTSP-om i komorbidnom depresijom u usporedbi s onima bez komorbidne depresije. Veća koncentracija trombocitnog serotonina i veća učestalost LL genotipa polimorfizma 5-HTTLPR u usporedbi s nositeljima S alela utvrđena je u veterana s PTSP-om sa simptomima rane nesanice u usporedbi s veteranima bez rane nesanice. S druge strane, različiti poremećaji spavanja nisu bili značajno povezani s genotipovima polimorfizma 5-HTTLPR ili s promijenjenom koncentracijom trombocitnog serotonina u veterana s PTSP-om i komorbidnom depresijom.

Abstract (english)

Post-Traumatic Stress Disorder (PTSD) is a complex psychiatric disorder that develops after traumatic experience(s). Sleep disorders, including nightmares and insomnia, are one of the main features of PTSD. Although the neurobiological basis of PTSD is unclear, it involves complex interactions of genetic and environmental factors. Due to its role in controlling mood, arousal, and sleep, serotonin system is important for development of PTSD symptoms. The aim of the study was to determine the possible association of serotonin transporter gene polymorphism and platelet serotonin concentration with sleep disorders in 393 Croatian war veterans with PTSD. 5-HTTLPR polymorphism genotypes were similarly distibuted in veterans with PTSD and control subjects. The distribution of 5-HTTLPR polymorphism genotypes was similar in veterans with PTSD with and without comorbid depression, while platelet serotonin concentrations were lower in veterans with PTSD and comorbid depression in comparison to veterans without comorbid depression. Higher platelet serotonin concentration and higher incidence of LL 5-HTTLPR polymorphism genotypes compared to S alleles was found in veterans with PTSD with symptoms of early insomnia compared to veterans without early insomnia. In veterans with PTSD and comorbid depression various sleep disorders were not associated with 5-HTTLPR polymorphism genotypes or with altered platelet serotonin concentration.

• Keywords: PTSP; depresija; poremećaji spavanja; trombocitni serotonin; serotoninski prijenosnik; 5-HTTLPR polimorfizam
• Keywords (english): PTSD; depression; sleep disorders; platelet serotonin; serotonin transporter; 5-HTTLPR polymorphism
• Language: croatian
• URN:NBN: urn:nbn:hr:217:238241
• Study programme: Title: Experimental Biology; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-09-07 09:58:44