Trombocitni serotonin u djece s poremećajem pažnje i hiperaktivnošću

master's thesis

• Title (english): Platelet serotonin in children with attention deficit/ hyperactivity disorder
• Author: Ines Petek
• Mentor: Nela Pivac (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2009, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

Poremećaj pažnje s hiperativnošću (ADHD) je psihijatrijski poremećaj, čija neurobiološka osnova nije potpuno jasna, ali je povezana sa promijenjenim funkcioniranjem dopaminergičkog, noradrenergičkog i serotonergičkog (5-HT) sustava. Koncentracija trombocitnog 5-HT promijenjena je u određenim ponašanjima (agresivno, impulzivno) i kognitivnim poremećajima, koji prate ADHD. U radu su korišteni trombociti kao ograničeni periferni model središnjih 5-HT sinaptosoma, jer slično spremaju, otpuštaju i metaboliziraju 5-HT. Koncentraciju trombocitnog 5-HT odredili smo u skupinama djece s ADHD i kontrolne zdrave djece, te istražili mogući utjecaj spola na koncentraciju trombocitnog 5-HT. Rezultati su pokazali nedostatak značajnih razlika u koncentraciji trombocitnog 5-HT između muške i ženske djece oboljele od ADHD i zdrave djece. Nisu pronađene spolno uvjetovane razlike u koncentraciji trombocitnog 5-HT. Ti podaci upućuju na zaključak da ADHD nije vezan za promijenjenu koncentraciju trombocitnog 5-HT. Periferni biološki pokazatelj kao što je trombocitni 5-HT vezan je za određena ponašanja ili simptome promijenjene u ADHD, i njegova se koncentracija ne može se koristiti kao periferni biološki pokazatelj kompleksnog dijagnostičkog entiteta kao što je ADHD.

Abstract (english)

Attention deficit/ hyperactivity disorder (ADHD) is a psychiatric disorder with unclear neurobiological background, thought to be associated with altered dopaminergic, noradrenergic and serotonergic (5-HT) systems functions. Platelet 5-HT concentration is changed in particular behaviors (aggressive, impulsive) and cognitive disturbances, related to ADHD. The study used platelets as a limited peripheral model of the central 5-HT synaptosomes, since they use, release and metabolize 5-HT similarly as central 5-HT synaptosomes. Platelet 5-HT concentration was determined in groups of children with ADHD and healthy control children, and the possible influence on sex on platelet 5-HT concentration was also evaluated. The results showed the lack of significant differences in platelet 5-HT concentration between boys and girls with ADHD and control boys and girls. No significant sex related differences in platelet 5-HT concentration were found. The findings suggest that ADHD is not associated with altered platelet 5-HT concentration. Peripheral biological marker such as platelet 5-HT is related to specific behaviors or symptoms altered in ADHD, and platelet 5-HT concentration could not be used as a peripheral biological marker of a complex diagnostic entity such as ADHD.

• Keywords: serotonin (5-HT); trombociti; ADHD; djeca
• Keywords (english): serotonin (5-HT); platelets; ADHD; children
• Language: croatian
• URN:NBN: urn:nbn:hr:217:942470
• Study programme: Title: Integrated undergraduate and graduate university study of Biology and Chemistry Education; specializations in: Integrated undergraduate and graduate university study of Biology and Chemistry Education; Course: Integrated undergraduate and graduate university study of Biology and Chemistry Education; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-15 09:07:48