Utjecaj gama zračenja na stabilnost rosuvastatina u vodenim otopinama

master's thesis

• Title (english): Gamma radiation impact on stability of rosuvastatin in water solutions
• Author: Lucija Dončević
• Mentor: Mario Cindrić (mentor)
• Committee member: Morana Dulić (predsjednik povjerenstva)
• Committee member: Nives Galić (član povjerenstva)
• Committee member: Vesna Petrović Peroković (član povjerenstva)
• Committee member: Aleksandra Maršavelski (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2020-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Vodeći uzrok smrtnosti u svijetu su kardiovaskularne bolesti. Uzrokovane su povećanom
koncentracijom lipoproteina, čijim gomilanjem na meandrima krvnih žila nastaje
aterosklerozni plak te uzrokuje perpetuirano ometanje protoka krvi. Bolesnici koji pate od
hiperlipoproteinemije konzumiraju lijekove tzv. statine, koji inhibiraju djelovanje enzima 3-
hidroksi-3-metilglutarilkoenzim A-reduktaze potrebnog za sintezu kolesterola. U konačnici,
statini uzrokuju uklanjanje viška štetnih lipoproteina u krvi. Rosuvastatin uzrokuje manje
nuspojava od ostalih lijekova skupine statina te ima pleiotropno djelovanje neovisno o
primarnoj svrsi djelovanja. Svrha ovog rada bila je ispitati razgradne produkte rosuvastatina i
njegovu strukturnu stabilnost nakon ozračivanja uzorka gama zrakama pomoću 60Co izvora
zračenja. Identifikacija produkata provedena je nanoUPLC-ESI-MS/MS sustavom, kojim je
određen elementni sastav šest razgradnih produkata rosuvastatina.

Abstract (english)

Cardiovascular diseases are one of the leading causes of death globally. They usually arise
when high levels of lipoproteins in meanders of blood vessels form an atherosclerotic plaque
which then obstructs blood circulation. Patients diagnosed with hyperlipoproteinemia use
drugs called statins that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A reductase required
for cholesterol synthesis. Ultimately, statins eliminate adverse lipoproteins from blood.
Rosuvastatin causes less side effects than other drugs in the statin group and possesses
pleiotropic effects independent of its primary use. The purpose of this study was to investigate
rosuvastatin degradation products and structural stability when exposed to gamma radiation
using 60Co. Subsequent analysis was performed by nanoUPLC-ESI-MS/MS which
determined elemental composition of six degradation products of rosuvastatin.

• Keywords: kardiovaskularne bolesti; rosuvastatin; inhibitori HMG-CoA-reduktaze; gama zračenje; nanoUPLC-ESI-MS/MS
• Keywords (english): cardiovascular diseases; rosuvastatin; gamma radiation; HMG-CoA reductase inhibitors; nanoUPLC-ESI-MS/MS
• Language: croatian
• URN:NBN: urn:nbn:hr:217:084638
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-10-12 10:51:46