Priprava i karakterizacija makrozonskog 4'' derivata azitromicina izvedenog iz 4-aminobenzojeve kiseline i salicilaldehida te njegova kompleksa s niklom(II) i bakrom(II)

master's thesis

• Title (english): Synthesis and characterization of a macrozone 4'' derivative of azithromycin derived from 4-aminobenzoic acid and salicylaldehyde and its complex with nickel(II) and copper(II)
• Author: Monika Galić
• Mentor: Predrag Novak (mentor)
• Mentor: Kristina Smokrović (komentor)
• Committee member: Predrag Novak (predsjednik povjerenstva)
• Committee member: Đani Škalamera (član povjerenstva)
• Committee member: Jana Pisk (član povjerenstva)
• Committee member: Tomislav Jednačak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2023-07-03, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Porast rezistencije bakterija na antibiotike koji su trenutno na tržištu potaknuo je potrebu za
otkrivanjem novih. Makrolidni antibiotik azitromicin koristi se za liječenje bolesti uzrokovanih
Gram-pozitivnim i Gram-negativnim bakterijama. Makrozoni su konjugati azitromicina i
tiosemikarbazona pripremljeni za liječenje infekcija uzrokovanih rezistentnim bakterijama, s
potencijalom zaobilaženja razvijenih mehanizama rezistencije. Kako bi se dodatno povećala
biološka aktivnost i farmakološka svojstva, napravljeni su kompleksi tiosemikarbazona s
metalnim ionima. U ovom radu prvo je pripravljen tiosemikarbazon izveden iz 4-
aminobenzojeve kiseline i salicilaldehida. Nakon toga, dobiveni tiosemikarbazon je vezan na
4''-aminopropilni derivat azitromicina dajući pripadajući makrozon. Istražena je mogućnost
kompleksiranja s ionima bakra(II) i nikla(II). Sintetizirani spojevi karakterizirani su
spektroskopijom NMR.

Abstract (english)

The increase in bacterial resistance to currently marketed antibiotics has prompted the need to
discover new ones. The macrolide antibiotic azithromycin is used to treat diseases caused by
Gram-positive and Gram-negative bacteria. Macrozones are conjugates of azithromycin and
thiosemicarbazones prepared to treat infections caused by resistant bacteria, with potential of
bypassing the developed resistance mechanisms. In order to further increase biological activity
and pharmacological properties thiosemicarbazone complexes with metal ions have been made.
In this work, a thiosemicarbazone derived from 4-aminobenzoic acid and salicylaldehyde was
prepared first. Subsequently, the resulting thiosemicarbazone was bound to the 4''-aminopropyl
derivative of azithromycin. The possibility of complexation with copper (II) and nickel (II) ions
was explored. The synthesized compounds were characterized by NMR spectroscopy.

• Keywords: azitromicin; makrozon; spektroskopija NMR; tiosemikarbazon
• Keywords (english): azithromycin; macrozone; NMR spectroscopy; thiosemicarbazone
• Language: croatian
• URN:NBN: urn:nbn:hr:217:195567
• Project: Number: IP-2018-01-8098; Title: Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije; Title: Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions; Acronym: Makrozoni/Macrozones; Leader: Predrag Novak; Jurisdiction: Croatia; Funder: HRZZ; Funding stream: IP
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-07-04 13:51:16