Dermatoglifi u autoimunoj hipotireozi i hipertireozi – sličnosti i razlike

doctoral thesis

• Title (english): Dermatoglyphics in autoimmune hypothyreosis and hyperthyreosis – similarities and differences
• Author: Jelena Vučak Lončar
• Mentor: Dario Rahelić (mentor)
• Mentor: Jasna Miličić (sumentor); MBZ: 84255
• Committee member: Pavao Rudan (član povjerenstva)
• Committee member: Ana Galov (član povjerenstva)
• Committee member: Velimir Božikov (član povjerenstva); MBZ: 5053
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2014, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 577 - Biochemistry. Molecular biology. Biophysics

Abstract

Autoimune bolesti štitnjače – Gravesova bolest (hipertireoza) i Hashimotova bolest (hipotireoza), najčešće su bolesti štitnjače, ali i najčešća autoimuna oboljenja uopće, koja pogađaju oko 2 do 5% ukupne populacije. Prevalencija im raste s godinama, a u oba slučaja oko 10 puta češće obolijevaju žene. Kako su digito-palmarni dermatoglifi pokazatelji fenomena rasta i diferencijacije tijekom razdoblja rane embriogeneze, njihova analiza korištena je u istraživanju uloge naslijeđa u nastanku ovih bolesti, u otkrivanju za njih specifičnih biljega te u nastojanju da se ispita izdvajanje ovih bolesti u kontekstu bioloških skupina. Provedena je analiza razlika kvalitativnih i kvantitativnih svojstava dermatoglifa između skupine od 100 žena oboljelih od hipotireoze, 50 oboljelih od hipertireoze te kontrolne skupine od 100 fenotipski zdravih žena. Slijedom rezultata istraživanja koji upućuju na statistički značajne heterogenosti, zaključujemo da se bolesnice s autoimunim bolestima štitnjače izdvajaju kao posebna biološka skupina, razlikuju se i međusobno u latentnom prostoru, što ukazuje na ulogu različitih genskih polimorfizama i okolišnih čimbenika u etiologiji njihovog nastanka.

Abstract (english)

Hypothyreosis and hyperthyreosis are the most common autoimmune diseases. Their prevalence has been increasing over the years and in both cases women are about 10 times more affected. Dermatoglyphics are the indicators of growth phenomenon and the differentiation during the early stage of embryogenesis. Therefore analysis of digital-palmar dermatoglyphics has been used in the research of the role of heritage in the development of these diseases, also in detecting their specific markers and revealing the idea of their separation in the context of biological groups. The aim of this paper was to analyze the qualitative and quantitative characteristics of the digital and palmar dermatoglyphics between the group of 100 females with hypothyreosis, 50 females with hyperthyreosis and a control group of 100 phenotypically healthy females. The statistical analysis has shown the heterogenity between all examined groups. The results of the research have proved that patients with thyroid autoimmune diseases separate as specific biological group, there are also differences between hypothyreosis and hyperthyreosis in latent space, so we conclude that different polymorphisms of genes together with influence of enviroment are taking part in their development.

• Keywords: hipotireoza; hipertireoza; dermatoglifi; etiologija; genetska predispozicija; okoliš
• Keywords (english): hypothyreosis; hyperthyreosis; dermatoglyphics; etiology; genetic predisposition; enviroment
• Language: croatian
• URN:NBN: urn:nbn:hr:217:301804
• Study programme: Title: Biology; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2017-05-18 12:19:19