Kronično zatajenje bubrega i prilagodbe na hibernaciju kod sisavaca

undergraduate thesis

• Title (english): Chronic kidney failure and mammalian adaptations during hibernation
• Author: Monika Trupinić
• Mentor: Duje Lisičić (mentor)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2016, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology

Abstract

S rastućom ljudskom populacijom, raste broj bolesti koje bitno smanjuju kvalitetu života. Kronične bolesti bubrega spadaju u jedne od najraširenijih bolesti ljudi za koje nemamo trajno rješenje. Do toga mogu dovesti različiti uzročnici, a velika poveznica vidi se s pretilošću koja često dovodi do hipertenzije i dijabetesa. Bubrezi, kao organi koji održavaju homeostazu cjelokupnog organizma, nisu zamjenjivi i svaka nepravilnost u radu postaje alarmantna. Mnoge današnje metode liječenja pomažu u održavanju normalnog stanja organizma tamo gdje bubreg više ne može, međutim takve terapije su iscrpne i potrebno ih je konstantno ponavljati. Jedno od mogućih rješenja u budućem liječenju bolesti bubrega znanstvenici su vidjeli u prirodi. Životinje u stanju hibernacije ne unose hranu, vodu, ne kreću se i ne izbacuju fekalije, međutim njihov organizam ostaje funkcionalan i bez posljedica. Najzanimljiviji su medvjedi koji imaju jedinstvenu sposobnost recikliranja ureje, stvarajući proteine. Ako bismo otkrili na koji način, tj. koji geni i mehanizmi su uključeni u taj proces, mogli bismo to iskoristiti u liječenju pacijenata koji više nemaju funkcionalne bubrege.

Abstract (english)

With growing human population, we can also see growth in the number of diseases that influence the quality of life. Chronic kidney diseases are one of the most common human diseases that we can't permanently cure. Various causes may lead to chronic kidney disease but there is visible correlation with obesity which often leads to hypertension and diabetes. Kidneys, as organs who are greatly responsible for body homeostasis, are not replaceable and every malfunction is alarming. Modern medicine and therapies help to keep normal bodily functions in departments that kidneys are not capable anymore, but those treatments are often exhausting for patients and need to be repeated constantly. One possible solution in future treatments of kidney diseases can find its inspiration in nature. Hibernating animals don't eat, drink, move or urinate, and are still completely healthy without any conseqences. The most interesting animals are bears with their unique ability to recycle urea into proteins. If we can determine genes and mechanisms involved in this process, maybe we could use it in future treatments of patients whose kidneys have failed.

• Keywords: bolesti bubrega
• Keywords (english): kidney diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:217:679117
• Study programme: Title: Molecular Biology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-04 11:02:25