Poboljšanje topljivosti loratadina uslijed kompleksiranja s odabranim ciklodekstrinima

master's thesis

• Title (english): Improvement of loratadine solubility by complexation with cyclodextrins
• Author: Nina Mamić
• Mentor: Nives Galić (mentor)
• Committee member: Nives Galić (predsjednik povjerenstva)
• Committee member: Ines Primožič (član povjerenstva)
• Committee member: Željka Soldin (član povjerenstva)
• Committee member: Adriana Kenđel (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2021-01-29, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Loratadin (LOR) je antihistaminik druge generacije koji prema biofarmaceutskom sustavu
klasifikacije spada u skupinu slabo topljivih djelatnih tvari (skupina Ⅱ). Međutim, utvrđeno je
da mu se topljivost povećava ukoliko je u kompleksu s ciklodekstrinom. U ovom radu
istražen je utjecaj β-ciklodekstrina i njegovog derivata hidroksipropil-β-ciklodekstrina na
topljivost loratadina u vodi i biorelevantnim medijima (pH 4,5 i 6,8). Loratadin je
kvantitativno određen tekućinskom kromatografijom visoke djelotvornosti i UV/Vis
spektrofotometrijom. Kompleksi u čvrstom stanju pripremljeni su mljevenjem u
visokoenergetskim mlinovima uz dodatak male količine otapala, kao i bez otapala. Za potvrdu
nastanka kompleksa korištena je infracrvena spektroskopija tehnikom prigušene totalne
refleksije i u transmisijskom načinu snimanja.

Abstract (english)

Loratadine is a second-generation antihistamine that is categorized in the Biopharmaceutics
Classification System as a poorly water-soluble drug (BSC II class). However, studies have
shown that its solubility increases with the addition of cyclodextrin. In this thesis, the effect of
β-cyclodextrin and hydroxypropyl-β-cyclodextrin on the solubility of loratadine in water and
biorelevant media (pH 4.5 and 6.8), was studied. High-performance liquid chromatography
and UV/Vis spectrophotometry were used for the quantitative determination of loratadine.
Solid loratadine-cyclodextrin inclusion complexes were prepared by grinding in high energy
vibrational mills with the addition of small catalytic amounts of solvent and also without
solvent. Infrared spectroscopy was used to confirm the formation of the complexes, using the
technique of attenuated total reflection and the transmission mode.

• Keywords: ciklodekstrini; inkluzijski kompleksi; loratadin; mehanokemijska aktivacija; topljivost
• Keywords (english): cyclodextrins; inclusion complex; loratadine; mechanochemical activation; solubility
• Language: croatian
• URN:NBN: urn:nbn:hr:217:015578
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2023-01-29
• Created on: 2021-03-08 10:57:24