Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

Risteski, Patrik; Božan, Domagoj; Jagrić, Mihaela; Bosilj, Agneza; Pavin, Nenad; Tolić, Iva M.

doi:10.1016/j.celrep.2022.111169

prikaz prve stranice dokumenta Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

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Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment

Cell Reports, 40 (2022), 5; 111169. https://doi.org/10.1016/j.celrep.2022.111169

Risteski, Patrik; Božan, Domagoj; Jagrić, Mihaela; Bosilj, Agneza; Pavin, Nenad; Tolić, Iva M.

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APA 6th Edition

Risteski, P., Božan, D., Jagrić, M., Bosilj, A., Pavin, N. i Tolić, I. M. (2022). Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment. Cell Reports, 40. (5). doi: 10.1016/j.celrep.2022.111169

MLA 8th Edition

Risteski, Patrik, et al. "Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment." Cell Reports, vol. 40, br. 5, 2022. https://doi.org/10.1016/j.celrep.2022.111169

Chicago 17th Edition

Risteski, Patrik, Domagoj Božan, Mihaela Jagrić, Agneza Bosilj, Nenad Pavin i Iva M. Tolić. "Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment." Cell Reports 40, br. 5 (2022). https://doi.org/10.1016/j.celrep.2022.111169

Harvard

Risteski, P., et al. (2022) 'Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment', Cell Reports, 40(5). doi: 10.1016/j.celrep.2022.111169

Vancouver

Risteski P, Božan D, Jagrić M, Bosilj A, Pavin N, Tolić IM. Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment. Cell Reports [Internet]. 08.2022. [pristupljeno 22.08.2024.];40(5). doi: 10.1016/j.celrep.2022.111169

IEEE

P. Risteski, D. Božan, M. Jagrić, A. Bosilj, N. Pavin i I. M. Tolić, "Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment", Cell Reports, vol. 40, br. 5, Kolovoz 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:995052. [Citirano: 22.08.2024.]

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Naslov (engleski)	Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment
Autor	Patrik Risteski
Autor	Domagoj Božan
Autor	Mihaela Jagrić
Autor	Agneza Bosilj
Autor	Nenad Pavin
Autor	Iva M. Tolić
Autorova ustanova	Sveučilište u Zagrebu Prirodoslovno-matematički fakultet (Fizički odsjek)
Znanstveno / umjetničko područje, polje i grana	PRIRODNE ZNANOSTI Fizika
Sažetak (engleski)	Chromosome alignment at the spindle equator promotes proper chromosome segregation and depends on pulling forces exerted at kinetochore fiber tips together with polar ejection forces. However, kinetochore fibers are also subjected to forces driving their poleward flux. Here we introduce a flux-driven centering model that relies on flux generated by forces within the overlaps of bridging and kinetochore fibers. This centering mechanism works so that the longer kinetochore fiber fluxes faster than the shorter one, moving the kinetochores toward the center. We develop speckle microscopy in human spindles and confirm the key prediction that kinetochore fiber flux is length dependent. Kinetochores are better centered when overlaps are shorter and the kinetochore fiber flux slower than the bridging fiber flux. We identify Kif18A and Kif4A as overlap and flux regulators and NuMA as a fiber coupler. Thus, length-dependent sliding forces exerted by the bridging fiber onto kinetochore fibers support chromosome alignment.
Ključne riječi (engleski)
Jezik	engleski
Vrsta publikacije	Znanstveni rad - Izvorni znanstveni rad
Status objave	Objavljen
Vrsta recenzije	Recenziran - međunarodna recenzija
Verzija publikacije	Objavljena verzija rada (izdavačev PDF)
Naslov časopisa	Cell Reports
Brojčani podaci	vol. 40, br. 5, 111169
p-ISSN	2211-1247
DOI	https://doi.org/10.1016/j.celrep.2022.111169
URN:NBN	urn:nbn:hr:217:995052
Datum objave publikacije	2022-08
Projekt	Šifra: 855158 Naziv (hrvatski): Molekularno podrijetlo aneuploidija u zdravim i bolesnim ljudskim tkivima Naziv (engleski): Molecular origins of aneuploidies in healthy and diseased human tissues Kratica: ANEUPLOIDY Voditelj: Iva Marija Tolić Pravna nadležnost: eu Financijer: Europska komisija
Projekt	Šifra: 647077 Naziv (hrvatski): Nova klasa mikrotubula u vretenu koja djeluje silama na kinetohore Naziv (engleski): A new class of microtubules in the spindle exerting forces on kinetochores Kratica: NewSpindleForce Voditelj: Iva Marija Tolić Pravna nadležnost: eu Financijer: Europska komisija
Projekt	Šifra: PZS-2019-02-7653 Naziv (hrvatski): Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena Naziv (engleski): Mechanisms of microtubule bundle formation required for spindle maturation Kratica: SpindleForm Voditelj: Iva Marija Tolić Pravna nadležnost: Hrvatska Financijer: Hrvatska zaklada za znanost Linija financiranja: Programme Research Cooperability
Projekt	Šifra: IP-2019-04-5967 Naziv (hrvatski): Ravnoteža sila i momenta sila u diobenom vretenu Naziv (engleski): Balance of forces and torques in the mitotic spindle Kratica: SpindleForceBalance Voditelj: Nenad Pavin Pravna nadležnost: Hrvatska Financijer: Hrvatska zaklada za znanost Linija financiranja: Research Projects
Projekt	Šifra: KK.01.1.1.04.0057 Naziv (hrvatski): Inovativni protokoli mikroskopije za interdisciplinarna istraživanja u biomedicini Naziv (engleski): Inovative microscopy protocols for interdisciplinary research in biomedicine Kratica: IPSted Voditelj: Iva Marija Tolić Pravna nadležnost: eu Financijer: Europska komisija Linija financiranja: European Regional Development Fund
Projekt	Šifra: KK.01.1.1.01.0004 Naziv (hrvatski): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri Naziv (engleski): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras Kratica: QuantiXLie Voditelj: Hrvoje Buljan Pravna nadležnost: eu Financijer: Europska komisija Linija financiranja: European Regional Development Fund
URL dokumenta	https://linkinghub.elsevier.com/retrieve/pii/S2211124722009822
Vrsta resursa	Tekst
Prava pristupa	Otvoreni pristup
Uvjeti korištenja
Javna napomena	© 2022 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Published 2 August 2022.
Datum i vrijeme pohrane	2024-08-22 09:17:12