prikaz prve stranice dokumenta Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
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Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
Advanced Materials Technologies, 7 (2022), 9; 2101159. https://doi.org/10.1002/admt.202101159
Schmidt, Tony; Jakešová, Marie; Đerek, Vedran; Kornmueller, Karin; Tiapko, Oleksandra; Bischof, Helmut; Burgstaller, Sandra; Waldherr, Linda; Nowakowska, Marta; Baumgartner, Christian; Üçal, Muammer; Leitinger, Gerd; Scheruebel, Susanne; Patz, Silke; Malli, Roland; Głowacki, Eric Daniel; Rienmüller, Theresa; Schindl, Rainer Više autora...

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Schmidt, T., Jakešová, M., Đerek, V., Kornmueller, K., Tiapko, O., Bischof, H. ... Schindl, R. (2022). Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision. Advanced Materials Technologies, 7. (9). doi: 10.1002/admt.202101159

Schmidt, Tony, et al. "Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision." Advanced Materials Technologies, vol. 7, br. 9, 2022. https://doi.org/10.1002/admt.202101159

Schmidt, Tony, Marie Jakešová, Vedran Đerek, Karin Kornmueller, Oleksandra Tiapko, Helmut Bischof, Sandra Burgstaller, et al. "Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision." Advanced Materials Technologies 7, br. 9 (2022). https://doi.org/10.1002/admt.202101159

Schmidt, T., et al. (2022) 'Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision', Advanced Materials Technologies, 7(9). doi: 10.1002/admt.202101159

Schmidt T, Jakešová M, Đerek V, Kornmueller K, Tiapko O, Bischof H, i sur.. Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision. Advanced Materials Technologies [Internet]. 18.03.2022. [pristupljeno 03.12.2024.];7(9). doi: 10.1002/admt.202101159

T. Schmidt, et al., "Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision", Advanced Materials Technologies, vol. 7, br. 9, Ožujak 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:217:840752. [Citirano: 03.12.2024.]

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Naslov (engleski)Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
AutorTony Schmidt
AutorMarie Jakešová
AutorVedran Đerek
AutorKarin Kornmueller
AutorOleksandra Tiapko
AutorHelmut Bischof
AutorSandra Burgstaller
AutorLinda Waldherr
AutorMarta Nowakowska
AutorChristian Baumgartner
AutorMuammer Üçal
AutorGerd Leitinger
AutorSusanne Scheruebel
AutorSilke Patz
AutorRoland Malli
AutorEric Daniel Głowacki
AutorTheresa Rienmüller
AutorRainer Schindl
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
(Fizički odsjek)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Fizika
Sažetak (engleski)
Nongenetic optical control of neurons is a powerful technique to study and manipulate the function of the nervous system. This research has benchmarked the performance of organic electrolytic photocapacitor (OEPC) optoelectronic stimulators at the level of single mammalian cells: human embryonic kidney (HEK) cells with heterologously expressed voltage-gated K+ channels and hippocampal primary neurons. OEPCs act as extracellular stimulation electrodes driven by deep red light. The electrophysiological recordings show that millisecond light stimulation of OEPC shifts conductance-voltage plots of voltage-gated K+ channels by ≈30 mV. Models are described both for understanding the experimental findings at the level of K+ channel kinetics in HEK cells, as well as elucidating interpretation of membrane electrophysiology obtained during stimulation with an electrically floating extracellular photoelectrode. A time-dependent increase in voltage-gated channel conductivity in response to OEPC stimulation is demonstrated. These findings are then carried on to cultured primary hippocampal neurons. It is found that millisecond time-scale optical stimuli trigger repetitive action potentials in these neurons. The findings demonstrate that OEPC devices enable the manipulation of neuronal signaling activities with millisecond precision. OEPCs can therefore be integrated into novel in vitro electrophysiology protocols, and the findings can inspire in vivo applications.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAdvanced Materials Technologies
Brojčani podacivol. 7, br. 9, 2101159
p-ISSN2365-709X
e-ISSN2365-709X
DOIhttps://doi.org/10.1002/admt.202101159
URN:NBNurn:nbn:hr:217:840752
Datum objave publikacije2022-03-18
ProjektŠifra: UIP-2019-04-1753
Naziv (hrvatski): Mikro i nano-strukture za 3D opto-bioelektroniku
Naziv (engleski): Micro- and nano-structures for 3D opto-bioelectronics
Kratica: 3Doptobio
Voditelj: Vedran Đerek
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Installation Research Projects
ProjektŠifra: KK.01.1.1.02.0013
Naziv (hrvatski): Centar za Napredna Istraživanja Kompleksnih Sustava
Naziv (engleski): Centre for Advanced Research of Complex Systems
Kratica: CeNIKS
Voditelj: Mihael Srđan Grbić
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
ProjektŠifra: KK.01.1.1.01.0004
Naziv (hrvatski): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri
Naziv (engleski): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras
Kratica: QuantiXLie
Voditelj: Hrvoje Buljan
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/admt.202101159
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Javna napomena© 2022 The Authors. Advanced Materials Technologies published byWiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution License, which permits use, distribution andreproduction in any medium, provided the original work is properly cited. First published: 18 March 2022.
Datum i vrijeme pohrane2024-08-09 18:26:26