Experimental methods in functional genomics

završni rad

• Autor: Ivan Mikičić
• Mentor: Kristian Vlahoviček (mentor)
• Ustanova koja je dodijelila akademski / stručni stupanj: Sveučilište u Zagrebu; Prirodoslovno-matematički fakultet; (Biološki odsjek); Zagreb
• Datum i država obrane: 2015, Hrvatska
• Znanstveno / umjetničko područje, polje i grana: PRIRODNE ZNANOSTI; Biologija

Sažetak

Over the past few years, massively parallel DNA sequencing platforms have become widely available, dramatically reducing the cost of DNA sequencing. The fast and low-cost sequencing approaches not only change the landscape of genome sequencing projects but also usher in new opportunities for sequencing in various applications, among other in functional genomics. The aim of functional genomics studies is to understand the complex relationship between genotype and phenotype on a genome-wide scale. Studies investigate a range of processes such as transcription, translation and epigenetic regulation, in an attempt to answer relevant biological questions. Newly developed techniques, such as RNA-seq, ChIP-seq and 3C-based methods found their use in some of the most massive projects, such as the ENCODE project. The aim of this review was to introduce some of the most common techniques in functional genomics and to explain their possibilities, advances, applications and challenges.

• Ključne riječi: experimental methods; functional genomics
• Jezik: engleski
• URN:NBN: urn:nbn:hr:217:648584
• Studijski program: Naziv: Molekularna biologija; Vrsta studija: sveučilišni; Stupanj studija: preddiplomski; Akademski / stručni naziv: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (univ. bacc. biol. mol.)
• Vrsta resursa: Tekst
• Način izrade datoteke: Izvorno digitalna
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2017-12-21 12:29:03