Start/stop Codon-like Trinucleotides (CLTs) and Extended Clusters as New Language of DNA

Znanstveni rad - Prethodno/kratko priopćenje

• Autor: Marija Rosandić
• Autor: Matko Glunčić
• Autor: Vladimir Paar
• Autorova ustanova: Sveučilište u Zagrebu; Prirodoslovno-matematički fakultet; (Fizički odsjek)
• Znanstveno / umjetničko područje, polje i grana: PRIRODNE ZNANOSTI; Fizika

Sažetak (engleski)

DNA nucleotide sequences carry genetic information of different kinds, not just coding instructions for protein synthesis. They can play a role, for example, in alternative conformations and gene regulators. The present paper introduces the extended start/stop codon-like trinucleotides (CLTs) for noncoding DNA sequences, based on trinucleotide cluster extension generated by specific single-nucleotide multiplications. Extended cluster analysis gives rise to rich information potential as a "new language" of DNA ("CLT-language"). The analysis of start/stop-CLTs extended clusters provides qualitative and quantitative differentiation and characterization of alpha satellites, as well as of other repetitive and non-repetitive noncoding sequences. As a measure of CLT extension of DNA sequences the extension factor r is introduced. Start/stop CLTs enable a distinction of three segments within alpha satellite, the first and the second as wrapping sequences and the third as a linker. Within a linker there are no start/stop CLTs. On the basis of start/stop-CLTs, it is hypothesized that these noncoding sequences may be involved in the networks of gene regulators.

• Ključne riječi (engleski): alpha satellites; start/stop codons; nucleosome; cluster extension; gene regulators
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Prethodno/kratko priopćenje
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Croatica Chemica Acta
• Brojčani podaci: vol. 84, br. 2, str. 334-341
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• DOI: https://doi.org/10.5562/cca1948
• URN:NBN: urn:nbn:hr:217:097023
• Datum objave publikacije: 2011
• Projekt: Šifra: 119-0982464-1253; Naziv (hrvatski): KSA kompjutorsko istraživanje repeticija višeg reda i duplikona u humanom genomu; Voditelj: Vladimir Paar; Pravna nadležnost: Hrvatska; Financijer: MZOS; Linija financiranja: ZP
• URL dokumenta: https://hrcak.srce.hr/71995
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2019-11-03 17:56:31