Međudjelovanja kolatnog aniona s površinski aktivnim tvarima, kelirajućim ligandom i metalnim ionima

doctoral thesis

• Title (english): Interactions of cholate anion with surface active agents, chelating ligand and metal ions
• Author: Tea Mihelj; MBZ: 318483
• Mentor: Vlasta Tomašić (mentor); MBZ: 49791
• Committee member: Tajana Preočanin (predsjednik povjerenstva)
• Committee member: Vlasta Tomašić (član povjerenstva); MBZ: 49791
• Committee member: Dubravka Matković-Čalogović (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2015-04-17, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry
• Universal decimal classification (UDC): 54 - Chemistry. Crystallography. Mineralogy

Abstract

U cilju istraživanja utjecaja strukture na fizikalno-kemijska svojstva krutih spojeva s biološki aktivnim kolatnim anionom (Ch), sintetizirana su tri tipa kompleksa (katanionski, metaloamfifilni i gostdomaćin) skloni stvaranju supramolekulskih membrana. Korišten je niz eksperimentalnih tehnika: CHN analiza, NMR, IR spektroskopija, DSC, difrakcija rentgenskih zraka (WAXD i SAXD), mikroskopija (SM i SEM), te DFT računi. Katanionski amfifili sintetizirani su interakcijom natrijevog kolata (NaCh) i kvaternih amonijevih soli, varirajući broj n-dodecilnih lanaca na ionskoj grupi (nc), odn. broj ionskih grupa (nh) u molekuli. Struktura katanionika na sobnoj temperaturi (RT) je atipična dvoslojna, a na povišenim temperaturama smektička (Sm); ispitivana je zavisnost polimorfnih i mezomorfnih svojstava, termodinamičkih parametara i debljine dvosloja o nc i nh. Metaloamfifili su pripravljeni interakcijom NaCh s Ag(I), Ca(II), Ba(II) i La(III) solima, te neutralizacijom Ag(I) oksida ili Ca(II) hidroksida kolnom kiselinom. Interakcija Ch i metalnih kationa u područjima viših koncentracija rezultira geliranjem, s bidentantnom koordinacijom Ch. Adicijom NaCh; natrijevog 4-(1-pentilheptil)benzensulfonata (NaDBS); n-dodecilsulfata (NaDS); odn. kalijevog pikrata (KP) u šupljinu 18C6 etera dobiveni su gostdomaćin kompleksi. Pri sobnoj temperaturi strukture su dvoslojne, dok s povišenjem temperature formiraju mezofaze, pretežno Sm (18C6.NaDS i 18C6.NaDBS) ili kolesteričke (18C6.NaCh).

Abstract (english)

In order to explain the effect of structural factors on the physico-chemical properties of solid compounds based on biologically active cholate ion (Ch), three types of complexes (catanionic, metaloamphiphilic and hostguest) that show tendency to form supramolecular membranes were synthesized. Various experimental techniques were used: CHN analysis, NMR, IR spectroscopy, DSC, X-ray diffraction (WAXD and SAXD), microscopy (POM i SEM), and DFT calculations. Catanionic amphiphiles were sythesized by the interaction of sodium cholate (NaCh) and quaternary ammonium salts, by varying the number of n-dodecyl chains on the ionic group (nc), and the number of ionic groups (nh) in the molecule. The room temperature (RT) structure of catanionics is atipical bilayer, and smectic (Sm) at higher temperatures. The dependence of polymorphic and mesomorphic properties, thermodynamic parameters and bilayer thickness on nc and nh was studied. Metaloamphiphiles were sythesized by the interaction of NaCh with Ag(I), Ca(II), Ba(II) or La(III) salts, and by neutralization of Ag(I) oxide or Ca(II) hydro(oxyde) with cholic acid. Interaction of Ch and metal cation at higher concentration range results in gelation, and bidentante coordination of Ch. Addition of NaCh; sodium 4-(1-pentylheptyl)benzenesulfonate (NaDBS); n-dodecylsulfate (NaDS); potassium picrate (KP) into the 18C6 ether cavity forms hostguest complexes. The RT phases of addition complexes are bilayered, while mesophases are formed at higher temperatures, mostly Sm (18C6.NaDS i 18C6.NaDBS) or cholesteric (18C6.NaCh).

• Keywords: katanionici; 18C6 eter; kolna kiselina; mezofaze; supramolekulske strukture
• Keywords (english): catanionics; 18C6 ether; cholic acid; mesophases; supramolecular structures
• Language: croatian
• URN:NBN: urn:nbn:hr:217:955983
• Study programme: Title: Doctoral study in chemistry; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
• Type of resource: Text
• Extent: 297 str. ; 30 cm
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-02-10 08:55:02