PREVENCIJA SMRTI STANICA USLIJED TERMIČKE OSTEONEKROZE PRIMJENOM NOVODIZAJNIRANIH MEDICINSKIH SVRDALA

doctoral thesis

• Title (english): PREVENTION OF CELL DEATH DUE TO THERMAL OSTEONECROSIS BY USING NEWLY DESIGNED MEDICAL DRILLS
• Author: Slaven Babić
• Mentor: Aljoša Matejčić (mentor)
• Committee member: Inga Urlić (predsjednik povjerenstva)
• Committee member: Biljana Balen (član povjerenstva)
• Committee member: Ivan Dobrić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Biology); Zagreb
• Defense date and country: 2022-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Biology
• Universal decimal classification (UDC): 57 - Biological sciences. Physical anthropology. Biodiversity

Abstract

Termička osteonekroza je oštećenje kosti koje nastaje tijekom medicinskih intervencija u
ortopediji i traumatologiji. Pri bušenju kosti dolazi do porasta temperature uz mjesto bušenja.
Kad porast temperature i vrijeme izlaganja povišenoj temperaturi premašuju kritične razine,
nastaju nepovratna oštećenja stanica. Da bi se termičko oštećenje kosti preveniralo, mjesto
bušenja potrebno je hladiti ili rabiti drukčiji dizajn svrdala od dosadašnjih, koja manje
zagrijavaju okolno tkivo. U tu svrhu dizajnirana su dvostupnjevana svrdla s više kombinacija
užeg i šireg stupnja te je uspoređena razlika porasta temperature sa standardnim svrdlima
bušenjem na umjetnom materijalu. Bušenje na kostima izvedeno je odabranim kombinacijama
svrdala s najvećim potencijalom smanjenja porasta temperature, a uzorci koštanog tkiva s ruba
provrta kvantitativno su histološki analizirani. Ovo istraživanje pokazalo je da se kod
dvostupnjevanih svrdala razvijaju manje temperaturu okolne kosti od standardnih svrdala te da
je oštećenje stanica proporcionalno porastu temperature. Dvostupnjevana svrdla primjenjiva su
u ortopediji i traumatologiji

Abstract (english)

Thermal osteonecrosis is bone damage that occurs during medical interventions in orthopaedics
and traumatology. The temperature in the procedures of drilling bones rises near the drilling
site. When the temperature rises and the time of exposure to elevated temperature exceeds
critical levels, irreversible cell damage occurs. In order to prevent thermal damage to the bone,
it is necessary to cool the drilling site or use a different design of drills, which causes less
temperatures and less damage to the surrounding tissue. For this purpose, two-stage drills with
several combinations of narrower and wider stages were designed, and the difference in
temperature rise was compared with standard drill bits, by drilling on artificial material. Drilling
on bone tissue samples was performed with selected drill combinations which proved to have
the greatest potential to reduce the temperature rise. These samples were quantitatively
histologically analyzed. This study showed that two-stage drills develop a lower bone
temperature than standard drills and that cell damage is proportional to temperature rise. Twostage drills are applicable in orthopaedic surgery.

• Keywords: traumatologija; ortopedija; termička osteonekroza; smrt stanice; medicinska svrdla
• Keywords (english): orthopaedic surgery; thermal osteonecrosis; cell death; surgical drills
• Language: croatian
• URN:NBN: urn:nbn:hr:217:550775
• Promotion: 2022
• Study programme: Title: Biology; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2024-09-20
• Created on: 2022-11-14 11:36:15