Visokotlačna supramolekulska sinteza kokristalâ lamotrigina

master's thesis

• Title (english): High pressure supramolecular synthesis of lamotrigine co-crystals
• Author: Edi Topić
• Mentor: Vladimir Stilinović (mentor)
• Committee member: Vladimir Stilinović (predsjednik povjerenstva)
• Committee member: Hrvoj Vančik (član povjerenstva)
• Committee member: Josip Požar (član povjerenstva)
• Committee member: Dominik Cinčić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Science; (Department of Chemistry); Zagreb
• Defense date and country: 2018-02-23, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry

Abstract

Ispitane su mogućnosti visokotlačne statičke i udarne kompresije kao metode za pripravu
kokristala lamotrigina, te uspoređene s mogućnostima uobičajenih metoda supramolekulske
sinteze. Provedeno je pretraživanje kokristala lamotrigina kristalizacijom iz otopine,
kristalizacijom iz taline te mehanokemijskom sintezom. Uzorci fizičke smjese lamotrigina i
koformera obrađeni su statičkom kompresijom pri dva tlaka, te sporom i brzom udarnom
kompresijom pri četiri različite brzine projektila. Dobiveni uzorci izučavani su metodom
difrakcije rentgenskih zraka na praškastom uzorku, razlikovnom pretražnom kalorimetrijom te
skenirajućom elektronskom mikroskopijom. Riješene su kristalne strukture za tri solvata i
jedan kokristal lamotrigina metodom difrakcije rentgenskog zračenja na jediničnom kristalu.
Visokotlačna sinteza i uobičajene metode sinteze uspoređene su prema broju uspješnih
priprava, morfologiji i mehanizmu nastanka kokristala.

Abstract (english)

High-pressure static and shock compression was studied and compared with common
methods used for supramolecular synthesis. Cocrystal screening of lamotrigine was done by
crystallization from solution, crystallization from melt and mechanochemical synthesis.
Physical mixture of lamotrigine and coformer was subjected to static compression at two
pressures, as well as slow and fast shock compression at four different projectile speeds.
Obtained samples were analysed with powder X-ray diffraction, differential scanning
calorimetry and scanning electron microscopy. Crystal structure was solved for three solvates
and one cocrystal of lamotrigine using single-crystal X-ray diffraction. High-pressure
supramolecular synthesis and common methods of cocrystal preparation were compared by
number of hits, morphology and formation mechanism of cocrystals.

• Keywords: supramolekulska sinteza; lamotrigin; visokotlačna kemija
• Keywords (english): supramolecular synthesis; lamotrigine; high-pressure chemistry
• Language: croatian
• URN:NBN: urn:nbn:hr:217:062988
• Study programme: Title: Graduate university studies in chemistry; specializations in: Research programme; Course: Research programme; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2020-02-23
• Created on: 2018-03-05 15:13:34