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Hidrazino - derivati aminokiselina u sintezi peptidomimetika
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Josipa Suć Peptidi i proteini imaju ključnu ulogu u nizu bioloških i fizioloških procesa; međutim, njihova primjena kao terapeutika je ograničena slabom stabilnošću i biodostupnošću. Stoga je razvoj peptidomimetika, spojeva koji oponašaju strukturu i/ili funkciju proteina od velikog značaja za akademsku zajednicu i farmaceutsku industriju. Cilj istraživanja predloženih u okviru doktorske disertacije je priprava peptidomimetika korištenjem hidrazino-derivata -aminokiselina. Istraživanja...
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Hidrazino-derivat glutaminske kiseline za derivatizaciju karbonilnih spojeva
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Lidija Brkljačić U okviru provedenih istraživanja osmišljen je i pripravljen novi reagens za derivatizaciju karbonilnih spojeva, hidrazino-derivat glutaminske kiseline, koji je upotrebljen za određivanje karbonilnih spojeva LC-MS/MS metodom. Istraživanje je obuhvatilo i njegovu karakterizaciju spektroskopskim i spektrometrijskim metodama. Reakcijom hidrazino-derivata glutaminske kiseline i odabranih karbonilnih spojeva dobiveni su Glu-hidrazoni, koji su prema potrebi reducirani u Glu-hidrazide. Nastali...
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Homogenization of the elastic plate equation
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Jelena Jankov The main goal of this thesis is to study homogenization of the Kirchhoff-Love model for pure bending of a thin symmetric elastic plate, which is described by the fourth order elliptic equation. Homogenization theory is one of the most successful approaches for dealing with optimal design problems (in conductivity or linearized elasticity), which consists of arranging given materials such that obtained body satisfies some optimality criteria, typically expressed mathematically as the...
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Hybrids of biomacromolecules and modern two-dimensional materials
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Ida Delač Marion Compared to bulk material, interfaces exhibit additional rich physical phenomena. Functionalized surfaces represent interfaces which are of great importance not only in fundamental surface and materials science but also for applications, which is additionally emphasized by the fact that most of the microelectronic devices used today are based on planar designs. One implementation of functionalized surfaces are hybrid materials. These bridge the gap between living matter and technology and...
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IDENTIFIKACIJA I BIOLOŠKA AKTIVNOST SLOBODNIH HLAPLJIVIH
SPOJEVA RODA Veronica L. (PLANTAGINACEAE)
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Marija Nazlić Odabrane vrste roda Veronica (čestoslavice, porodica Plantaginaceae) - V. saturejoides ssp.
saturejoides, V. austriaca ssp. jacquinii i V. officinalis, prikupljene su na prirodnim staništima
u Republici Hrvatskoj. Za ove vrste istražen je fitokemijski sastav slobodnih hlapljivih spojeva
eteričnih ulja i hidrosola plinskom kromatografijom-masenom spektrometrijom. Prevladavajući
spojevi bili su heksahidrofarnezil aceton i heksadekanska kiselina. Iste vrste testirane su na
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IMMUNOGLOBULIN G GLYCOSYLATION IN COVID-19 DISEASE
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Tea Pribić The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has become one of the major health problems in the world. SARS-CoV-2 infection leads to
a disease caused by coronavirus (COVID-19), with a spectrum of symptoms ranging from
asymptomatic to life-threatening pneumonia and death. A variation in the severity of disease
symptomsis one of the central questions in COVID-19 pandemics. Immunoglobulin G (IgG),
the most abundant glycoprotein in human blood plasma,...
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Identification and characterization of transposable elements in sponges (Porifera)
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Maja Kuzman Transposable elements constitute a large portion of most eukaryotic genomes and play an important role in transcriptional regulation, shaping gene regulatory networks and genome evolution. Due to a lack of quality genome assemblies of non-model organisms, not much is known about the diversity, distribution and the role of transposable elements across Metazoa. In this thesis I present high quality genome assemblies for the sponge species Eunapius subterraneus and Suberites domuncula. I use...
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Identification of the initial jet parton using machine learning techniques at the ALICE detector
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Marko Jerčić Quarks and gluons produced in high-energy collisions at the Large Hadron Collider (LHC) are manifested as collimated jets of particles via fragmentation and hadronisation processes. Distinguishing quark-initiated jets and gluon-initiated jets can be very useful for theoretical understanding of the fragmentation process, for better measurements of the Standard model parameters, as well as in the search for physics beyond the Standard model. Using machine learning techniques on data from the...
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Identified di-hadron angular correlations using the ALICE detector at the Large Hadron Collider
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Filip Erhardt Two-particle angular correlations are a useful tool to study the mechanisms of particle production by observing the angular separation (Δη, Δφ) between pairs of particles in an event. Different structures in the Δη − Δφ space are caused by various modes of particle production and interactions between particles shortly after production. Examining these structures can give us insight into the nature of these interactions. One of these structures is called “the Ridge” and its...
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Identifikacija endosimbiotskih odnosa hidre i alge primjenom metoda molekularne filogenije
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Nives Rajević Simbiotske asocijacije imaju široki značaj u evoluciji i bioraznolikosti. Proces endosimbioze jedan je od pokretača specijacije. Zelena hidra (Hydra viridissima Pallas, 1766) tipičan je primjer endosimbioze, jer u svojim gastrodermalnim mioepitelnim stanicama sadrži jednostanične fotoautotrofne alge. Endosimbiotske alge izolirane iz zelenih hidri sakupljenih s četiri različite lokacije u Hrvatskoj, te iz Izraela i iz Njemačke identificirane su koristeći pet molekularno...
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