Paginacija
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The effects of teleconnections on climate variability of the North Atlantic-European area
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Sara Ivasić Observed data, reanalysis and an intermediately complex general circulation model of the atmosphere (ICTP AGCM) have been employed to study the effects of teleconnections on the North Atlantic-European region as a part of this thesis. Modulation of the El Niño-Southern Oscillation (ENSO) teleconnection to the North Atlantic-European (NAE) region and its relationship with the North Atlantic Oscillation (NAO) have been tested via regression maps, running correlation, composite analysis and...
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The mechanisms of microtubule associated proteins in chromosome segregation
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Kruno Vukušić Successful cell division requires chromosomes to be separated on opposite sides of the cell. This
is achieved by depolymerisation of kinetochore fibers and spindle elongation. Forces required for
spindle elongation in human cells are linked to sliding of antiparallel microtubules and sliding
capacity has been demonstrated in vitro for multiple motor proteins, but the molecular mechanism
of sliding during anaphase in the spindles of human cells remains unknown. Here I show, by
using...
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The repair of Topoisomerase 1 and
2 DNA-protein crosslinks in vivo
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Ivan Antičević DNA-protein crosslinks (DPCs) are frequent and damaging DNA lesions that affect all DNA transactions, which can lead to the formation of DSBs (double-strand DNA breaks), genomic instability and cell death. At the organismal level, impaired DPC repair (DPCR) is associated with cancer, aging, and neurodegeneration. Repair of the two most abundant enzymatic DPCs, involving topoisomerase 1 and 2 was studied in cell models, but data from organisms are still limited. Here, using a zebrafish model...
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The role of brassinosteroids and salicylic acid in plant defense response to Potato spindle tuber viroid infection
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Jasna Milanović Viroids are plant–pathogenic molecules characterized by a single–stranded circular non–coding RNA
genome. Despite their genomic simplicity, these plant pathogens are able to induce disease in a wide
range of host plants with significant economic impact. The surveillance activities described in this
study, revealed the presence of Potato spindle tuber viroid (PSTVd) in Croatia in two ornamental
species, while no PSTVd infection was found in tomato or potato. This study was also...
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The role of bridging fibers in the architecture of the metaphase mitotic spindle
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Bruno Polak Mitosis is a fundamental process during which the genetic material is transferred to
daughter cells and is orchestrated by the mitotic spindle. Between two opposite spindle poles
microtubules form bundles that interact with chromosomes. Bundles that bind to kinetochores on
the chromosome are called kinetochore fibers, whilst certain microtubules form antiparallel
overlap bundles in the central part of the spindle. With this research localization and distribution
of antiparallel overlap...
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The role of bridging microtubules in anaphase of cell division
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Renata Buđa During cell division, microtubules of the mitotic spindle segregate chromosomes by exerting
forces on kinetochores, protein complexes on the chromosomes. The central question is which
forces drive chromosome segregation. The current model for anaphase in human cells
includes shortening of kinetochore fibers and separation of spindle poles, processes that
require kinetochore-pole connections. By combining laser ablation, photoactivation and
protein depletion, we show that kinetochores...
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The role of kinesin-8 and PRC1 proteins in kinetochorepositioning in the metaphase plate
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Mihaela Jagrić U metafazi mitoze kromosomi se poravnavaju u ekvatorijalnoj ravnini diobenog vretena što je
od ključne važnosti za pravilan završetak kasnijih faza. Poravnavanje kromosoma regulirano
je silama dinamike kinetohornih vlakana (k-vlakana) te silama odbijanja na polovima. U
ovome radu istražena je uloga kinezina-8 u poravnavanju kromosoma, koji je jedan od
glavnih regulatora dinamike k-vlakana. Pokazala sam kako kinezin-8 regulira brzinu i
amplitudu kretanja kinetohora, dok eksperimenti...
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The role of microtubule-associated
proteins in the generation and
regulation of spindle shape
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Monika Trupinić In the mitotic spindle, a complex micro-structure responsible for the segregation of chromosomes,
individual microtubule bundles obtain different shapes depending on the mechanical forces acting
on them. In addition to linear forces, rotational forces are present in the spindle, reflected in the
left-handed twisted shapes of microtubule bundles that make the spindle chiral. However, it is not
known how twist changes throughout mitosis in non-tumor cells, or what are the molecular...
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The role of solid-state reactivity in the prebiotic selection of nucleobases and formation of peptides
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Tomislav Stolar Within this thesis, solid-state reaction medium and mechanochemical methodologies were explored to unveil weather nucleobases can self-assemble and amino acids can oligomerize under these conditions. X-ray diffraction and differential scanning calorimetry analysis showed that 2,6-diaminopurine (D) selectively self-assembles with uracil (U) and thymine (T), while adenine (A) self-assembles with hypoxanthine (H). Crystal structures of D-U cocrystal hydrate, D-T cocrystal hydrate, D-T cocrystal...
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Thermodynamics and geometry of black holes in the presence of nonlinear electromagnetic fields
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Ana Bokulić Nonlinear electrodynamics (NLE) is an umbrella term for nonlinear modifications of Maxwell’s theory. The first NLE theories appeared as quantum corrections to Maxwell’s electrodynamics or in order to cure point charge singularities. Our focus is on NLE fields in the context of gravitational theory, their impact on the laws of black hole thermodynamics and the general geometric properties of spacetimes. Using a perturbative approach, we show that the solution for the Schwarzschild black...
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Theta liftovi ireducibilnih reprezentacija metaplektičke grupe
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Petar Bakić U ovoj disertaciji proučavaju se theta liftovi generičkih reprezentacija simplektičke, odnosno metaplektičke grupe definirane nad lokalnim nearhimedskim poljem F karakteristike 0. U radu odgovaramo na osnovna pitanja vezana uz theta korespondenciju: kada su promatrani liftovi različiti od nul-reprezentacije, te kako izgledaju ne-nul liftovi. Za potpuni odgovor na prvo pitanje koristimo Kudlinu filtraciju i rezultat G. Muića o ireducibilnosti standardnih modula generičkih...
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Three-dimensional elastic body and a Naghdi type shell interaction modelling
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Matko Ljulj In this thesis we analyse an interaction problem between two elastic three-dimensional bodies of which one is much thinner than the other. Furthermore, the thin body is assumed to be more stiff with elastic coefficients related to the small thickness parameter. We consider this problem in context of both linear and nonlinear elasticity. We analyse asymptotic behaviour of solutions of these problems and obtain different limit models in various regimes as thickness tends to zero. Furthermore,...
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