Paginacija
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Citokini u infekciji virusom ljudske imunodeficijencije tipa 1
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Lana Gorenec Cilj ovog istraživanja bio je usporediti ekspresiju citokina na razini gena i proteina u akutnoj i kroničnoj fazi infekcije HIV-om-1, te analizirati učinak dugotrajne supresije virusne replikacije u periodu duljem od dvije godine na citokinsku imunost. U dio istraživanja koji se bavi usporedbom citokinske imunosti na proteinskoj razini u akutnoj i kroničnoj fazi infekcije uključila sam 34 ispitanika, dok sam u istraživanje učinka dugotrajne supresije virusne replikacije na ekspresiju...
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Cjelogenomska asocijacijska studija masne tjelesne mase u stanovništvu otoka Visa
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Željka Tomas Pretilost je jedan od osnovnih faktora rizika za kardiovaskularna oboljenja, dijabetes, i zloćudne tumore. Iako su u pozadini porasta prevalencije pretilosti okolišni čimbenici, postoje značajne interindividualne varijacije u odgovoru na moderan stil života koje su dijelom posljedica razlika u genetičkoj predispoziciji pojedinca. Kako bi se istražili genetički i okolišni čimbenici koji utječu na pojavu pretilosti, provedena je cjelogenomska asocijacijska analiza udjela masti u...
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Classification of boundary conditions for Freidrichs systems
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Soni Sandeep Kumar This work is concerned with the classification of boundary conditions for the classical Friedrichs systems by developing new results on abstract Friedrichs operators. The concept of the classical Friedrichs system was introduced by Friedrichs in 1958 as a symmetric positive system of first-order linear partial differential equations. The main motivation was to treat the equations that change their type, like the Tricomi equation (which appears in the transonic flow). Moreover, it allows a...
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Clustering in neutron-rich light nuclei produced in reactions of 9Li beam on LiF target
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Nikola Vukman The results presented in this thesis are based on the analysis of the S1620 experiment performed at TRIUMF, where multi-nucleon and cluster transfer reactions of the 9^Li beam of 74.8 MeV on the ≈ 1 mg/cm2 LiF target were used to populate excited states of neutron-rich light nuclei 10^Be, 12^Be and 13^B. The main motivation behind this work was the need for experimental data to wage on the existence of molecular-like structures in the excited states of these nuclei and to resolve...
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Combinatorial optimization algorithms for (pseudo)alignment in bioinformatics
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Luka Borozan The field of bioinformatics is a fast growing interdisciplinary field with a strong contribution from mathematics and computer science. This thesis will deal with mathematical problems and algorithmic challenges from that field. Its first focus will be the comparison of hierarchic structures, mainly phylogenetic trees, which is used to explain various biological processes such as the evolution of the species. We will study mathematical models and algorithmic techniques which quantify the...
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Compaction of nucleic acids
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Sanjin Marion Packing of nucleic acids inside (naturally occurring) confined spaces presents an intriguing problem of compacting a long and highly charged polymer into a small space possibly crowded with other particles (proteins). For example, viruses have a large amount of genomic information that is encoded in nucleic acids packed in small spaces resulting in high densities of matter. The arising interactions are coupled to the confinement giving a more complex phase diagram than expected in bulk. In...
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Constraints on neutrino oscillation parameters implied by OPERA experiment data
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Budimir Kliček The OPERA experiment in the CNGS beam was designed to measure the appearance of tau neutrinos in the high purity muon neutrino beam. The physical run lasted for five years in the period 2008 - 2012 with the total accumulated CNGS intensity of 1.797 · 10^20 protons-on-target. The primary goal was achieved by observing five tau neutrino candidate events, which corresponds to the significance of the ν_τ observation of more than 5 σ. In addition to this, constraints on │Δm^2_32│ mass...
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Construction of molecular tools based on CRISPR/Cas9 system for epigenetic modulation of gene expression
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Vanja Tadić Repurposing of platforms for targeted genome engineering, zinc finger nucleases (ZFNs),
transcription activator-like nucleases (TALENs) and especially CRISPR/Cas9 system, has enabled
targeted manipulation of epigenetic marks and new insights into epigenetic regulatory mechanisms. In
this work, I have fused the catalytic domain of human TET1 (Ten-Eleven Translocation 1) protein Cterminally
to the catalytically inactive Cas9 (dCas9) from Streptococcus pyogenes to create the dCas9-
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Cosmic evolution of active galactic nuclei detected in the radio waveband
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Bruno Šlaus A major topic in the field of astrophysics is understanding the evolution of the Universe through cosmic time. Throughout the evolution of the Universe and galaxies, among the most interesting objects are galaxies containing active, super-massive black holes in their galactic centers, called active galactic nuclei (AGN). We model the evolution of AGN by constructing their radio luminosity functions. We use radio surveys of varying area and depth, namely the deep COSMOS survey of 1,916 AGN...
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Crosstalk of gene polymorphisms with RNA and protein phenotypic characteristics
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Marina Rudan Both RNA and protein molecules can misfold into non-functional conformations. Since DNA is transcribed into RNA to direct the biosynthesis of proteins, functional cells require the maintenance of DNA, RNA and protein homeostasis. Here, it is explored whether DNA polymorphisms can impact upon RNA and protein conformation to the extent of displaying phenotypic changes. It has been found that this is a multifaceted process. Mutation-induced protein conformational ...
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DIVERSITY OF DIATOM AND BACTERIAL COMMUNITIES ASSOCIATED
WITH LOGGERHEAD SEA TURTLES (CARETTA CARETTA)
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Klara Filek Loggerhead sea turtles are ancient marine reptiles inhabiting the oceans worldwide. They are
colonized by microorganisms both in the gastrointestinal tract and on their carapace and skin.
In this thesis that consists of four scientific publications, the loggerhead sea turtle-associated
diatom and bacterial communities were investigated by high-throughput sequencing of
chloroplast rbcL gene and 16S rRNA gene, and cultivation. The culture-independent approach
has shown that loggerheads...
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